지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
A humanized mice (hu-mice) model is extremely valuable to verify human cell activity in vivo condition and is regarded as an important tool in examining multimodal therapies and drug screening in tumor biology. Moreover, hu-mice models that simply received human CD34<SUP>+</SUP> blood cells and tissue transplants are also overwhelmingly useful in immunology and stem cell biology. Because generated hu-mice harboring a human immune system have displayed phenotype of human CD45<SUP>+</SUP> hematopoietic cells and when played partly with functional immune network, it could be used to evaluate human cell properties in vivo. Although the hu-mice model does not completely recapitulate human condition, it is a key methodological factor in studying human hematological malignancies with impaired immune cells. Also, an advanced humanized leukemic mice (hu-leukemic-mice) model has been developed by improving immunodeficient mice. In this review, we briefly described the history of development on immunodeficient SCID strain mice for hu-and hu-leukemic-mice model for immunologic and tumor microenviromental study while inferring the potential benefits of hu-leukemic-mice in cancer biology.
목차
INTRODUCTION
Development of hu-mice model
Development of hu-leukemic mice model
Application and perspectives of hu-leukemic mice model
CONCLUSION
REFERENCES
참고문헌 (49)
참고문헌 신청
[학술지(정기간행물)] - Ailles LE / 1999 / Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice / Blood 94 : 1761 ~ 1772
[학술지(정기간행물)] - Ayala F / 2009 / Contribution of bone microenvironment to Leukemogenesis and leukemia progression / Leukemia 23 : 2233 ~ 2241
[학술지(정기간행물)] - Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3 : 730 ~ 737
[학술지(정기간행물)] - Bosma GC / 1983 / A severe combined immunodeficiency mutation in the mouse / Nature 301 : 527 ~ 530
[학술지(정기간행물)] - Boyerinas B / 2013 / Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy / Blood 121 : 4821 ~ 4831
[학술지(정기간행물)] - Ayala F / 2009 / Contribution of bone microenvironment to Leukemogenesis and leukemia progression / Leukemia 23 : 2233 ~ 2241
[학술지(정기간행물)] - Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3 : 730 ~ 737
[학술지(정기간행물)] - Bosma GC / 1983 / A severe combined immunodeficiency mutation in the mouse / Nature 301 : 527 ~ 530
[학술지(정기간행물)] - Boyerinas B / 2013 / Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy / Blood 121 : 4821 ~ 4831
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UCI(KEPA) : I410-ECN-0101-2016-510-001658708