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Humanized (SCID) Mice as a Model to Study human Leukemia
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논문 기본 정보

Type
Academic journal
Author
Ji Yoon Lee (The Catholic University of Korea) Donghyun Curt Kim (Northeastern University) Hee-Je Kim (The Catholic University of Korea)
Journal
The Korean Society For Biomedical Laboratory Sciences Biomedical Science Letters Vol.21 No.2 KCI Accredited Journals
Published
2015.6
Pages
51 - 59 (9page)

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Result
Humanized (SCID) Mice as a Model to Study human Leukemia
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Abstract· Keywords

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A humanized mice (hu-mice) model is extremely valuable to verify human cell activity in vivo condition and is regarded as an important tool in examining multimodal therapies and drug screening in tumor biology. Moreover, hu-mice models that simply received human CD34<SUP>+</SUP> blood cells and tissue transplants are also overwhelmingly useful in immunology and stem cell biology. Because generated hu-mice harboring a human immune system have displayed phenotype of human CD45<SUP>+</SUP> hematopoietic cells and when played partly with functional immune network, it could be used to evaluate human cell properties in vivo. Although the hu-mice model does not completely recapitulate human condition, it is a key methodological factor in studying human hematological malignancies with impaired immune cells. Also, an advanced humanized leukemic mice (hu-leukemic-mice) model has been developed by improving immunodeficient mice. In this review, we briefly described the history of development on immunodeficient SCID strain mice for hu-and hu-leukemic-mice model for immunologic and tumor microenviromental study while inferring the potential benefits of hu-leukemic-mice in cancer biology.
#Humanized #Mice model #Acute myeloid leukemia

Contents

INTRODUCTION
Development of hu-mice model
Development of hu-leukemic mice model
Application and perspectives of hu-leukemic mice model
CONCLUSION
REFERENCES

References (49)

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[학술지(정기간행물)] - Ailles LE / 1999 / Growth characteristics of acute myelogenous leukemia progenitors that initiate malignant hematopoiesis in nonobese diabetic/severe combined immunodeficient mice / Blood 94 : 1761 ~ 1772 google schola [학술지(정기간행물)] - Ayala F / 2009 / Contribution of bone microenvironment to Leukemogenesis and leukemia progression / Leukemia 23 : 2233 ~ 2241 google schola [학술지(정기간행물)] - Bonnet D / 1997 / Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell / Nat Med 3 : 730 ~ 737 google schola [학술지(정기간행물)] - Bosma GC / 1983 / A severe combined immunodeficiency mutation in the mouse / Nature 301 : 527 ~ 530 google schola [학술지(정기간행물)] - Boyerinas B / 2013 / Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy / Blood 121 : 4821 ~ 4831 google schola

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