지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.13 No.1
- 발행연도
- 2024.1
- 수록면
- 10 - 20 (11page)
- DOI
- 10.7774/cevr.2024.13.1.10
이용수
초록· 키워드
오류제보하기
Animal models are essential in medical research for testing drugs and vaccines. These models differ from humans in various respects, so their results are not directly translatable in humans. To address this issue, humanized mice engrafted with functional human cells or tis sue can be helpful. We propose using humanized mice that support the engraftment of human hematopoietic stem cells (HSCs) without irradiation to evaluate vaccines that influence patient immunity. For infectious diseases, several types of antigens and adjuvants have been devel oped and evaluated for vaccination. Peptide vaccines are generally used for their capability to fight cancer and infectious diseases. Evaluation of adjuvants is necessary as they induce in flammation, which is effective for an enhanced immune response but causes adverse effects in some individuals. A trial can be done on humanized mice to check the immunogenicity of a particular adjuvant and peptide combination. Messenger RNA has also emerged as a potential vaccine against viruses. These vaccines need to be tested with human immune cells because they work by producing a particular peptide of the pathogen. Humanized mice with human HSCs that can produce both myeloid and lymphoid cells show a similar immune response that these vaccines will produce in a patient.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Recent Advances of Vaccine Adjuvants for Infectious Diseases
Immune Network
2015 .04
-
A method for increasing the frequency of human cells in humanized mouse model
한국실험동물학회 학술발표대회 논문집
2020 .07
-
Development of humanized immune mouse model to study cancer immunotherapies and other diseases
한국실험동물학회 학술발표대회 논문집
2021 .07
-
Humanized Animal Models for Studying the Efficacy of Vaccines Against Tularemia
한국실험동물학회 학술발표대회 논문집
2016 .02
-
Review of COVID-19 Vaccines and Their Evidence in Older Adults
Annals of geriatric medicine and research
2021 .01
-
Therapeutic Vaccines and Nucleic Acid Drugs for Cardiovascular Disease
지질·동맥경화학회지
2024 .09
-
Vaccines in the United States: a systematic review on history of evolution, regulations, licensing, and future challenges
Clinical and Experimental Vaccine Research
2020 .01
-
Novel Humanized Patient Derived Mouse Models for Immune-oncology Research
대한외과학회 학술대회 초록집
2020 .11
-
Increased B Cell Understanding Puts Improved Vaccine Platforms Just Over the Horizon
Immune Network
2022 .12
-
Should the COVID-19 Vaccine be Administered Simultaneously with Other Vaccines?
Infection and Chemotherapy
2021 .09
-
Potential Perturbations of Critical Cancer-regulatory Genes in Triple-Negative Breast Cancer Cells Within the Humanized Microenvironment of Patient-derived Xenograft Models
Journal of Breast Cancer
2024 .02
-
Exploring the experience of developing COVID-19 vaccines in Iran
Clinical and Experimental Vaccine Research
2023 .01
-
Current development of therapeutic vaccines for the treatment of chronic infectious diseases
Clinical and Experimental Vaccine Research
2024 .01
-
[S12-4] Humanized mice are essential tools for evaluation of cell and gene therapies to move towards a clinical trial
한국실험동물학회 학술발표대회 논문집
2024 .07
-
The Characteristics of RNA Vaccine
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Development of human liver disease models using liver-humanized chimeric mice
한국실험동물학회 학술발표대회 논문집
2019 .07
-
Ongoing Clinical Trials of Vaccines to Fight against COVID-19 Pandemic
Immune Network
2021 .02
-
CD47;Rag2;IL2rg triple KO mice preconditioning with busulfan injection could be a noble platform for generating hematopoietic stem cells engrafted humanized mice
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Recent advances in nano/microparticle-based oral vaccines
Journal of Pharmaceutical Investigation
2021 .01
-
[LS5] Humanized Models For Tumor Research
한국실험동물학회 학술발표대회 논문집
2024 .07
최근 본 자료
댓글(0)
0