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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 1990.12
- 수록면
- 115 - 122 (8page)
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초록· 키워드
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The effect of calcium influx blockers on the multiplication of Herpes simplex virus type 1 (HSV- 1) in human embryo fibroblast (HEF) cells was investigated. Various classes of calcium influx blockers, except for diltiazem, were similarly effective in inhibiting the prodution of infectious HSV- 1 and this inhibition was dose-, and time-dependent. Furhter stuides with verapamil, a prototype calcium influx blocker, revealed that the most sensitive events to the effects of calcium may occur during early times after HSV-1 infection of HEF cells. The inhibitory effect of calcium influx blockers on HSV-1 multiplication was partially reduced by increasing the concentration of calcium in the culture medium, supporting the previous observation on the effect of calcium influx blockers on HSV-1 multiplication. Calcium influx blockers also inhibitied HSV-1 DNA synthesis. This effect, however, seems to be due to nonspecific effects on host DNA synthesis machinery since the DNA synthesis in rnock-infected cells was inhibited by calcium influx blockers to levels comparable to or higher than the drug-mediated inhibition of HSV-1 DNA synthesis.
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