지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.9
- 수록면
- 141 - 150 (10page)
이용수
초록· 키워드
오류제보하기
Bacillus anthracis is a gram-positive, aerobic, spore forming, and rod-shaped bacterium. Anthrax spores are introduced into macrophage by phagocytosis and multiply after germination. The anthrax spores infected in macrophage produce lethal toxin eventually caused cell death. In this study, we analyzed apoptosis and cytokine TNF-α and IL-12 secretion after the infection of spores of B. anthracis Sterne in the murine macrophage RAW264.7 cells and in the primary human macrophages. In murine macrophage RAW264.7 cells infected by spore of B. anthracis Sterne, the cells were markedly changed in secretion of TNF-α (482~6,213 pg/㎖) by lethal toxin, and induced apoptosis. In case of RAW264.7 cells infected by formalin-inactivated spores of B. anthracis, the cells were not able to produce lethal toxin, which released lower level concentration of TNF-α (7.7~97.2 pg/㎖), and rarely induced apoptosis. When primary human macrophage cells infected with spores of B. anthracis Sterne, they secreted TNF-α (5~16 pg/㎖), and induced apoptosis about 1% of total cells. We presented that inducing apoptosis by spores of B. anthracis Sterne capable of expressing lethal toxin is related with the secretion of TNF-α in murine macrophage RAW264.7 cells. These studies revealed that human and murine macrophages has affected differently by anthrax lethal toxin produced by spores of B. anthracis Sterne.
목차
서론
재료 및 방법
결과
고찰
참고문헌
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Differential Effects of TNF-α on the Survival and Apoptosis of Human Granulocytes and the Human Myeloid Leukemia Cell Line
대한의생명과학회지
2013 .06
-
Suppression of bisphenol A on iNOS, IL-6 and TNF-$\alpha$in murine macrophages
대한약학회 학술대회
2001 .01
-
Antisense Technology를 이용한 탄저균 치사 독소 발현 억제
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2004 .12
-
IFN-$\gamma$ induction by TNF-$\alpha$ in mixed murine peritoneal macrophage-Tumor cell cultures
대한약학회 학술대회
2001 .01
-
Retroviral Vector를 이용한 TNF-$\alpha$ 유전자의 이입이 암세포의 종양괴사인자(TNF) 감수성에 미치는 효과
Tuberculosis and Respiratory Diseases
1994 .01
-
설치류 대식세포에서 목향(木香) 추출물의 항염증 효과
동의생리병리학회지
2011 .01
-
Down-regulation of iNOS, TNF-a and IL-6 gene expression by genistein in murine macrophages
대한약학회 학술대회
2001 .01
-
특이 표지인자로서의 Bacillus anthracis gyrB 유전자 유용성 분석
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2004 .09
-
Amplified Fragment Length Polymorphism에 의한 Bacillus anthracis의 분자분류 및 동정
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2001 .03
-
Meningitis Due to Bacillus Anthracis
Yonsei Medical Journal
2005 .01
-
Effect of Linarin, The main compound of Chrysanthemum zawadskiion, LPS-induced TNF-$\alpha$ production in murine macrophage cell line RAW 264.7 cells
대한약학회 학술대회
2001 .01
-
TNF에 대한 내성획득에서 MnSOD의 역할에 관한 연구
Tuberculosis and Respiratory Diseases
1997 .01
-
암세포에서 Retroviral Vector를 이용한 종양괴사인자 유전자 이입후 획득된 종양괴사인자 내성의 기전
Tuberculosis and Respiratory Diseases
1997 .01
-
The Effect of Linarin on LPS-Induced Cytokine Production and Nitric Oxide Inhibition in Murine Macrophages Cell Line RAW264.7
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
2002 .01
-
Inhibition of nitric oxide and TNF-$\alpha$ production by propenone compound through blockaded of NF-$\kappa$B activation in cultured murine macrophages
대한약학회 학술대회
2003 .01
-
Mechanisms Underlying Enterococcus faecalis-Induced Tumor Necrosis Factor-α Production in Macrophages
International Journal of Oral Biology
2010 .01
-
The Production of IFN-${\gamma}$ by 3LL/TNF-$\alpha$-Activated Macrophages Requires p38. JAK-2 Signalling and is Enhanced by New Protein Synthesis.
대한약학회 학술대회
2002 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0