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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 97 - 104 (8page)
이용수
초록· 키워드
오류제보하기
The skin exposure to solar irradiation and photoreactive xenobiotics may produce abnormal skin reaction, phototoxicity. Phototoxicity is an acute light-induced response, which occurs when photoreacive chemicals are activated by solar lights and transformed into products cytotoxic against the skin cells. Multifarious symptoms of phototoxicity are identified, skin irritation, erythema, pruritis, and edema that are similar to those of the exaggerated sunburn. Diverse organic chemicals, especially drugs, are known to induce phototoxicity, which is probably from the common possession of UV-absorbing benzene or heterocyclic rings in their molecular structures. Both UVB (290~320 nm) and UVA (320~400 nm) are responsible for the manifestation of phototoxicity. Absorption of photons and absorbed energy (hv) by photoactive chemicals results in molecular changes or generates reactive oxygen species and depending on the way how endogenous molecules are affected by phototoxicants, mechanisms of phototoxcity is categorized into two modes of action: Direct when unstable species from excited state directly react with the endogenous molecules, and indirect when endogeneous molecules react with secondary photoproducts. In order to identify phototoxic potential of a chemical, various test methods have been introduced. Focus is given to animal alternative test methods, i.e., in vitro, and in chemico assays as well as in vivo. 3T3 neutral red uptake assay, erythrocyte photohemolysis test, and phototoxicity test using human 3-dimensional (3D) epidermis model are examples of in vitro assays. In chemico methods evaluate the generation of reactive oxygen species or DNA strand break activity employing plasmid for chemicals, or drugs with phototoxic potential.
목차
DEFINITION OF PHOTOTOXICITY
MECHANISM OF PHOTOTOXICITY
TEST METHODS FOR PHOTOTOXICITY AND ANIMAL ALTERNATIVES
CONCLUSION
REFERENCES
참고문헌 (44)
참고문헌 신청
Freeman, A.K. / 2006 / Dermatologic diseases and problems. Geriatric Medicine / Springer :869~881
Boudon, S. M. / 2014 / Evaluation of Sparfloxacin Distribution by Mass Spectrometry Imaging in a Phototoxicity Model / J. Am. Soc. Mass Spectrom. 25:1803~1809
OECD / 2004 / Test No. 432: In vitro 3T3 NRU Phototoxicity Test / OECD Publishing. No. 432
Lugovic, L. / 2007 / Phototoxic and photoallergic skin reactions / Coll. Antropol. 31(Suppl 1):63~67
FDA U. / 2003 / Guidance for industry - Photosafety Testing / FDA Publishing :1~22
Boudon, S. M. / 2014 / Evaluation of Sparfloxacin Distribution by Mass Spectrometry Imaging in a Phototoxicity Model / J. Am. Soc. Mass Spectrom. 25:1803~1809
OECD / 2004 / Test No. 432: In vitro 3T3 NRU Phototoxicity Test / OECD Publishing. No. 432
Lugovic, L. / 2007 / Phototoxic and photoallergic skin reactions / Coll. Antropol. 31(Suppl 1):63~67
FDA U. / 2003 / Guidance for industry - Photosafety Testing / FDA Publishing :1~22
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UCI(KEPA) : I410-ECN-0101-2016-513-001692627