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자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.31 No.2
발행연도
2015.6
수록면
203 - 211 (9page)

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Trichloroacetonitrile is used as an intermediate in insecticides, pesticides, and dyes. In Korea alone, over 10 tons are used annually. Its oral and dermal toxicity is classified as category 3 according to the globally harmonized system of classification and labelling of chemicals, and it is designated a toxic substance by the Ministry of Environment in Korea. There are no available inhalation toxicity data on trichloroacetonitrile. Thus, the present study performed inhalation tests to provide data for hazard and risk assessments. Sprague-Dawley rats were exposed to trichloroacetonitrile at concentrations of 4, 16, or 64 ppm for 6 hour per day 5 days per week for 13 weeks in a repeated study. As a result, salivation, shortness of breath, and wheezing were observed, and their body weights decreased significantly (p < 0.05) in the 16 and 64 ppm groups. All the rats in 64 ppm group were dead or moribund within 4 weeks of the exposure. Some significant changes were observed in blood hematology and serum biochemistry (e.g., prothrombin time, ratio of albumin and globulin, blood urea nitrogen, and triglycerides), but the values were within normal physiological ranges. The major target organs of trichloroacetonitrile were the nasal cavity, trachea, and lungs. The rats exposed to 16 ppm showed moderate histopathological changes in the transitional epithelium and olfactory epithelium of the nasal cavity. Nasal-associated lymphoid tissue (NALT) and respiratory epithelium were also changed. Respiratory lesions were common in the dead rats that had been exposed to the 64 ppm concentration. The dead animals also showed loss of cilia in the trachea, pneumonitis in the lung, and epithelial hyperplasia in the bronchi and bronchioles. In conclusion, the no-observed-adverse-effect level (NOAEL) was estimated to be 4 ppm. The main target organs of trichloroacetonitrile were the nasal cavity, trachea, and lungs.
#Acute toxicity #Inhalation #Repeated toxicity #Trichloroacetonitrile #No-observed-adverseeffect level

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (11)

참고문헌 신청
Commission of the European Communities / 2001 / Strategy for a future chemical policy :4~32 google schola Ministry of Employment and Labor / 2013 / Notification on the exposure standard for chemical substances and physical properties / Notification No. 2013-38 google schola European Parliament and Council / 2006 / Regulatory framework for the management of chemicals (REACH) / European Chemicals Agency. Official Journal of the European Union :77~79 google schola Kalberlah, F. / 2007 / Harmonising OELs and DNELs at European Level-a position paper reflecting the results at the OELconference in Dortmund / Conference under the German Presidency of the European Council :304~320 google schola Ministry of Environment / 2014 / Chemical substance release inventory guideline / Ministry of Environment :304~320 google schola

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