지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- Korean Society for Precision Engineering Journal of the Korean Society for Precision Engineering Journal of the Korean Society for Precision Engineering Vol.32 No.8
- 발행연도
- 2015.8
- 수록면
- 755 - 760 (6page)
이용수
초록· 키워드
오류제보하기
For proper wound healing, dermal contraction and remodeling are critical; during the natural healing process, differentiated fibroblasts called “myofibroblasts” typically undertake these functions. For severe wounds, however, a critical mass of dermal matrix and fibroblasts are lost, making self-regeneration impossible. To overcome this impairment, synthetic wound patches with embedded functional cells can be used to promote healing. In this study, we developed a polydioxanone (PDO)-based cell-embedded sheet on which dermal fibroblasts were cultured and induced for differentiation into myofibroblasts, whereby the following combinatorial physicochemical stimuli were also applied: aligned topology, electric field (EF), and growth factor. The results show that both the aligned topology and EF synergistically enhanced the expression of alpha smoothmuscle actin (α-SMA), a key myofibroblast marker. Our proof-of-concept (POC) experiments demonstrated the potential applicability of a myofibroblast-embedded PDO sheet as a wound patch.
목차
1. 서론
2. 세포 배양 시스템 개발
3. 근섬유아세포로의 분화 촉진
4. 결론
REFERENCES
참고문헌 (15)
참고문헌 신청
박상철 / 2009 / 창상치료용 드레싱제로서의 알긴산염/알로에 함유 폴리비닐알콜 하이드로겔 패치 / 생체재료학회지 13(4):138~143
Murphy, P. S. / 2012 / Advances in Wound Healing: A Review of Current Wound Healing Products / Plastic Surgery International 2012
Vikatmaa, P. / 2008 / Negative Pressure Wound Therapy : A Systematic Review on Effectiveness and Safety / European Journal of Vascular and Endovascular Surgery 36(4):438~448
Cianfarani, F. / 2006 / Placenta Growth Factor in Diabetic Wound Healing / The American Journal of Pathology 169(4):1367~1182
Augustine, R. / 2014 / Advancement of Wound Care from Grafts to Bioengineered Smart Skin Substitutes / Progress in Biomaterials 3(2-4):103~113
Murphy, P. S. / 2012 / Advances in Wound Healing: A Review of Current Wound Healing Products / Plastic Surgery International 2012
Vikatmaa, P. / 2008 / Negative Pressure Wound Therapy : A Systematic Review on Effectiveness and Safety / European Journal of Vascular and Endovascular Surgery 36(4):438~448
Cianfarani, F. / 2006 / Placenta Growth Factor in Diabetic Wound Healing / The American Journal of Pathology 169(4):1367~1182
Augustine, R. / 2014 / Advancement of Wound Care from Grafts to Bioengineered Smart Skin Substitutes / Progress in Biomaterials 3(2-4):103~113
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UCI(KEPA) : I410-ECN-0101-2016-555-001787503