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Characteristics of nonalcoholic fatty liver disease induced in wistar rats following four different diets
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논문 기본 정보

Type
Academic journal
Author
Nicole Fakhoury-Sayegh (Saint Joseph University) Viviane Trak-Smayra (Saint Joseph University) Aline Khazzaka (Joseph University) Fady Esseily (Lebanese University) Omar Obeid (American University of Beirut) May Lahoud-Zouein (Lebanese University) Hassan Younes (Institut Polytechnique LaSalle Beauvais)
Journal
The Korean Nutrition Society Nutrition Research and Practice Vol.9 No.4 KCI Accredited Journals SCIE
Published
2015.8
Pages
350 - 357 (8page)

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Characteristics of nonalcoholic fatty liver disease induced in wistar rats following four different diets
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BACKGROUND/OBJECTIVES: The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased worldwide in parallel with overnutrition characterized by high-fat and high-carbohydrate intake. Our objective was to establish, in 16 weeks, a model of NAFLD in Wistar pathogen-free rats following four dietary types.
MATERIALS/METHODS: Forty (6 weeks old) healthy Wistar male rats, weighing an average of 150 g were randomly divided into four groups of ten and assigned a diet with the same quantity (15 g/rat/day), but with different composition. The moderate-fat (MF) group was fed a moderate-fat diet (31.5% fat and 50% carbohydrates), the high-fat (HF) group was fed a fat-rich diet (51% fat), the high-sucrose (HS) group and the high-fructose (HFr) group were fed a carbohydrate-rich diet (61%). The carbohydrate contents of the HS group was composed of 60.3% sucrose while that of the HFr group was composed of 59.3% fructose.
RESULTS: At week 16, the HF group had the highest percentage of cells enriched in fat (40%) and the highest weight and liver weight (P < 0.05). The HFr group showed significantly higher levels of serum triglycerides, alanine aminotransferase and adiponectin at week 16 as compared to week 1 (P < 0.05).
CONCLUSIONS: The 15 g/rat/day diet composed of 51% fat or 61% carbohydrates enriched mainly in fructose may induce characteristics of NAFLD in rats.
#Adiponectin #sucrose #triglycerides #fructose #Wistar rats

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INTRODUCTION
MATERIALS AND METHODS
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