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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.8
- 수록면
- 122 - 126 (5page)
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Transforming growth factor-β (TGF-β) is a highly pleiotropic cytokine playing pivotal roles in immune regulation. TGF-β facilitates tumor cell survival and metastasis by targeting multiple cellular components. Focusing on its immunosuppressive functions, TGF-β antagonists have been employed for cancer treatment to enhance tumor immunity. TGF-β antagonists exert anti-tumor effects through #1 activating effector cells such as NK cells and cytotoxic CD8<sup>+</sup> Tcells (CTLs), #2 inhibiting regulatory<SUP>pressor cell populations, #3 making tumor cells visible to immune cells, #4 inhibiting the production of tumor growth factors. This review focuses on the effect of TGF-β<</SUP> on T cells, which are differentiated into effector T cells or newly identified tumor-supporting T cells.
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