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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.2
- 수록면
- 74 - 93 (20page)
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초록· 키워드
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IL-17 is produced by RAR-related orphan receptor gamma t (RORγt)-expressing cells including Th17 cells, subsets of γδT cells and innate lymphoid cells (ILCs). The biological significance of IL-17-producing cells is well-studied in contexts of inflammation, autoimmunity and host defense against infection. While most of available studies in tumor immunity mainly focused on the role of T-bet-expressing cells, including cytotoxic CD8+ T cells and NK cells, and their exhaustion status, the role of IL-17-producing cells remains poorly understood. While IL-17-producing T-cells were shown to be anti-tumorigenic in adoptive T-cell therapy settings, mice deficient in type 17 genes suggest a protumorigenic potential of IL-17-producing cells. This review discusses the features of IL-17-producing cells, of both lymphocytic and myeloid origins, as well as their suggested pro- and/or antitumorigenic functions in an organ-dependent context. Potential therapeutic approaches targeting these cells in the tumor microenvironment will also be discussed.
목차
ABSTRACT
INTRODUCTION
PRODUCERS OF IL-17 IN THE TUMOR MICROENVIRONMENT
TISSUE-SPECIFIC NICHE DIVERSIFIES TYPE 17 RESPONSES
TYPE 17 CELLS AS PROGNOSIS FACTORS AND THERAPEUTIC TARGETS
CONCLUSIONS AND FUTURE PERSPECTIVES
REFERENCES
참고문헌 (145)
참고문헌 신청
Pelletier M / 2010 / Evidence for a cross-talk between human neutrophils and Th17 cells / Blood 115:335~343
Mangan PR / 2006 / Transforming growth factor-β induces development of the TH17 lineage / Nature 441:231~234
Chung Y / 2009 / Critical regulation of early Th17 cell differentiation by interleukin-1 signaling / Immunity 30:576~587
McGeachy MJ / 2009 / The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo / Nat Immunol 10:314~324
Ivanov II / 2006 / The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells / Cell 126:1121~1133
Mangan PR / 2006 / Transforming growth factor-β induces development of the TH17 lineage / Nature 441:231~234
Chung Y / 2009 / Critical regulation of early Th17 cell differentiation by interleukin-1 signaling / Immunity 30:576~587
McGeachy MJ / 2009 / The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo / Nat Immunol 10:314~324
Ivanov II / 2006 / The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells / Cell 126:1121~1133
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