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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 198 - 205 (8page)
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초록· 키워드
오류제보하기
A crucial limitation of DNA vaccines is its weak immunogenicity, especially in terms of eliciting antibody responses in non-human primates or humans; therefore, it is essential to enhance immune responses to vaccination for the development of successful DNA vaccines for humans. Methods: Here, we approached this issue by evaluating interleukin-7 (IL-7) as a genetic adjuvant in cynomolgus monkeys immunized with multigenic HCV DNA vaccine. Results: Codelivery of human IL-7 (hIL-7)-encoding DNA appeared to increase DNA vaccine-induced antibody responses specific for HCV E2 protein, which plays a critical role in protecting from HCV infection. HCV-specific T cell responses were also significantly enhanced by codelivery of hIL-7 DNA. Interestingly, the augmentation of T cell responses by codelivery of hIL-7 DNA was shown to be due to the enhancement of both the breadth and magnitude of immune responses against dominant and subdominant epitopes. Conclusion: Taken together, these findings suggest that the hIL-7-expressing plasmid serves as a promising vaccine adjuvant capable of eliciting enhanced vaccine-induced antibody and broad T cell responses.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
1. [학술지(정기간행물)] - Kiyosawa K / 1990 / Transition of antibody to hepatitis C virus from chronic hepatitis to hepatocellular carcinoma / Jpn J Cancer Res 81 : 1089 ~ 1091
2. [학술지(정기간행물)] - Alter MJ / 1999 / The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 / N Engl J Med 341 : 556 ~ 562
3. [학술지(정기간행물)] - Nascimbeni M / 2003 / Kinetics of CD4＋ and CD8＋ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees / J Virol 77 : 4781 ~ 4793
4. [학술지(정기간행물)] - Lanford RE / 2004 / Cross-genotype immunity to hepatitis C virus / J Virol 78 : 1575 ~ 1581
5. [학술지(정기간행물)] - Folgori A / 2006 / A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees / Nat Med 12 : 190 ~ 197
2. [학술지(정기간행물)] - Alter MJ / 1999 / The prevalence of hepatitis C virus infection in the United States, 1988 through 1994 / N Engl J Med 341 : 556 ~ 562
3. [학술지(정기간행물)] - Nascimbeni M / 2003 / Kinetics of CD4＋ and CD8＋ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees / J Virol 77 : 4781 ~ 4793
4. [학술지(정기간행물)] - Lanford RE / 2004 / Cross-genotype immunity to hepatitis C virus / J Virol 78 : 1575 ~ 1581
5. [학술지(정기간행물)] - Folgori A / 2006 / A T-cell HCV vaccine eliciting effective immunity against heterologous virus challenge in chimpanzees / Nat Med 12 : 190 ~ 197
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학술자료 II: DNA vaccine의 연구(硏究).개발동향(開發動向)
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Adjuvant-그 분류 및 작용방법에 대한 개관
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1997 .01
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