지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.6
- 수록면
- 71 - 83 (13page)
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초록· 키워드
오류제보하기
T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion. High resolution microscopy indeed had a great impact in understanding the function and dynamic structure of immunological synapse. Trends of recent research are now moving towards understanding the mechanical part of immune system, expanding our knowledge in mechanosensitivity, force generation, and biophysics of cell-cell interaction. Actin cytoskeleton plays inevitable role in adaptive immune system, allowing it to bear dynamic and precise characteristics at the same time. The regulation of mechanical engine seems very complicated and overlapping, but it enables cells to be very sensitive to external signals such as surface rigidity. In this review, we focus on actin regulators and how immune cells regulate dynamic actin rearrangement process to drive the formation of immunological synapse.
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등록된 정보가 없습니다.
참고문헌 (132)
참고문헌 신청
1. [학술지(정기간행물)] - Huppa, J. B / 2003 / T-cell-antigen recognition and the immunological synapse / Nat. Rev. Immunol 3 : 973 ~ 983
2. [학술지(정기간행물)] - Grakoui, A / 1999 / The immunological synapse: a molecular machine controlling T cell activation / Science 285 : 221 ~ 227
3. [학술지(정기간행물)] - Monks, C. R / 1998 / Three-dimensional segregation of supramolecular activation clusters in T cells / Nature 395 : 82 ~ 86
4. [학술지(정기간행물)] - Cemerski, S / 2006 / Immune synapses in T-cell activation / Curr. Opin. Immunol 18 : 298 ~ 304
5. [학술지(정기간행물)] - Saito, T. / 2006 / Immunological synapse and microclusters: the site for recognition and activation of T cells / Curr. Opin. Immunol 18 : 305 ~ 313
2. [학술지(정기간행물)] - Grakoui, A / 1999 / The immunological synapse: a molecular machine controlling T cell activation / Science 285 : 221 ~ 227
3. [학술지(정기간행물)] - Monks, C. R / 1998 / Three-dimensional segregation of supramolecular activation clusters in T cells / Nature 395 : 82 ~ 86
4. [학술지(정기간행물)] - Cemerski, S / 2006 / Immune synapses in T-cell activation / Curr. Opin. Immunol 18 : 298 ~ 304
5. [학술지(정기간행물)] - Saito, T. / 2006 / Immunological synapse and microclusters: the site for recognition and activation of T cells / Curr. Opin. Immunol 18 : 305 ~ 313
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