지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.10
- 수록면
- 217 - 221 (5page)
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초록· 키워드
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Fibroblast-like synoviocytes (FLS) colocalize with leukocyte infiltrates in rheumatoid synovia. Proinflammatory leukocytes are known to amplify inflammation by signaling to FLS, but crosstalk between FLS and regulatory T cells (Tregs) remains uncharacterized. To address this possibility, we cocultured FLS lines derived from arthritic mice with Tregs. FLS that expressed the ligand for glucocorticoid-induced TNF receptor family-related gene (GITR) decreased expression of Foxp3 and GITR in Tregs in a contact-dependent manner. This effect was abolished by blocking antibody to GITR. On the other hand, the Tregs caused the FLS to increase IL-6 production. These results demonstrate that inflamed FLS license Tregs to downregulate Foxp3 expression via the GITRL/GITR interaction while the Tregs induce the FLS to increase their production of IL-6. Our findings suggest that the interaction between FLS and Tregs dampens the anti-inflammatory activity of Tregs and amplifies the proinflammatory activity of FLS, thereby exacerbating inflammatory arthritis.
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참고문헌 (19)
참고문헌 신청
Jang, E. / 2006 / 5Prevention of spontaneous arthritis by inhibiting homeostatic expansion of autoreactive CD4+ T cells in the K/BxN mouse model / Arthritis. Rheum 54:492~498
Chang, S. K. / 2010 / Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11 / Immunol. Rev 233:256~266
Cao, D. / 2003 / Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis / Eur. J. Immunol 33:215~223
Nguyen, L. T. / 2007 / Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis / Arthritis. Rheum 56:509~520
장은경 / 2011 / Deficiency of Foxp3^+ Regulatory T Cells Exacerbates Autoimmune Arthritis by Altering the Synovial Proportions of CD4^+ T Cells and Dendritic Cells / Immune Network 11(5):299~306
Chang, S. K. / 2010 / Fibroblast-like synoviocytes in inflammatory arthritis pathology: the emerging role of cadherin-11 / Immunol. Rev 233:256~266
Cao, D. / 2003 / Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis / Eur. J. Immunol 33:215~223
Nguyen, L. T. / 2007 / Where FoxP3-dependent regulatory T cells impinge on the development of inflammatory arthritis / Arthritis. Rheum 56:509~520
장은경 / 2011 / Deficiency of Foxp3^+ Regulatory T Cells Exacerbates Autoimmune Arthritis by Altering the Synovial Proportions of CD4^+ T Cells and Dendritic Cells / Immune Network 11(5):299~306
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