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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 89 - 99 (11page)
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Graft-versus-host disease (GVHD) is a fatal complication that occurs after allogeneic hematopoietic stem cell transplantation. To understand the dynamics of CD4 and CD8 T cell production of IFN-γ and IL-17 during GVHD progression, we established a GVHD model by transplanting T cell-depleted bone marrow (TCD-BM) and purified T cells from B6 mice into irradiated BALB.B, creating an MHC-matched but minor histocompatibility (H) antigen-mismatched transplantation (B6 → BALB.B GVHD). Transplantation-induced GVHD was confirmed by the presence of the appropriate compositional changes in the T cell compartments and innate immune cells in the blood and the systemic secretion of inflammatory cytokines. Using this B6 → BALB.B GVHD model, we showed that the production of IFN-γ and IL-17 by CD4 T cells preceded that by CD8 T cells in the spleen, mesenteric lymph node, liver, and lung in the BALB.B GVHD host, and Th1 differentiation predated Th17 differentiation in all organs during GVHD progression. Such changes in cytokine production were based on changes in cytokine gene expression by the T cells at different time points during GVHD development. These results demonstrate that both IFN-γ and IL-17 are produced by CD4 and CD8 T cells but with different kinetics during GVHD progression.
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참고문헌 (34)
참고문헌 신청
1. [학술지(정기간행물)] - Blazar, B. R. / 2012 / Advances in graft-versus-host disease biology and therapy / Nat. Rev. Immunol 12 : 443 ~ 458
2. [학술지(정기간행물)] - Shlomchik, W. D. / 2007 / Graft-versus-host disease / Nat. Rev. Immunol 7 : 340 ~ 352
3. [학술지(정기간행물)] - Filipovich, A. H. / 2005 / National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biology of blood and marrow transplantation / Biol. Blood Marrow Transplant 11 : 945 ~ 956
4. [학술지(정기간행물)] - Socie, G / 2009 / Acute graft-versus-host disease: from the bench to the bedside / Blood 114 : 4327 ~ 4336
5. [학술지(정기간행물)] - Sun, Y. / 2007 / Pathophysiology of acute graft-versus-host disease: recent advances / Transl. Res 150 : 197 ~ 214
2. [학술지(정기간행물)] - Shlomchik, W. D. / 2007 / Graft-versus-host disease / Nat. Rev. Immunol 7 : 340 ~ 352
3. [학술지(정기간행물)] - Filipovich, A. H. / 2005 / National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report. Biology of blood and marrow transplantation / Biol. Blood Marrow Transplant 11 : 945 ~ 956
4. [학술지(정기간행물)] - Socie, G / 2009 / Acute graft-versus-host disease: from the bench to the bedside / Blood 114 : 4327 ~ 4336
5. [학술지(정기간행물)] - Sun, Y. / 2007 / Pathophysiology of acute graft-versus-host disease: recent advances / Transl. Res 150 : 197 ~ 214
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