지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 166 - 174 (9page)
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초록· 키워드
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In this study, an efficient whole cell-based biotransformation for the production of liquiritigenin was developed using Laetiporus sulphureus CS0218 as biocatalyst and aqueous extracts of Glycyrrhiza uralensis as co-substrate, respectively. In order to determine the efficacy of this method, the optimal bioconversion conditions including mycelial growth, three important enzyme activities (β-glucosidase, α-rhamnosidase and β-xylosidase), and apparent viscosity of culture broth were monitored. After optimization, aqueous extracts of G. uralensis were added to the culture medium to directly produce algycone liquiritigenin. By applying this strategy, 67.5% of liquiritin was converted to liquiritigenin at pH 3.0 after 9 days of incubation and finally liquiritigenin was purified from the reaction mixture. And then, their biological activities including anti-oxidant and superoxide dismutase were observed. In fact, purified liquiritigenin was capable of bi-directional functions (i.e., either up-regulation or down-regulation of SIRT1 which is associated with aging). The results indicate that this strategy would be beneficial to produce biologically active liquiritigenin and could be used in pharmaceutical, cosmetic and food applications.
목차
Abstract
1. INTRODUCTION
2. MATERIALS AND METHODS
3. Results and Discussion
4. Conclusion
REFERENCES
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Kim, Y. W. / 2006 / Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine / Chem. Biol. Interact 161 : 125 ~ 138
[학술지(정기간행물)] - Lee, J. Y. / 2009 / Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not / Int. Immunopharmacol 9 : 632 ~ 638
[학술지(정기간행물)] - Zhao, Z. / 2008 / Antidepressantlike effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats / Behav. Brain Res 194 : 108 ~ 113
[학술지(정기간행물)] - Kim, Y. W. / 2008 / Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-êB-dependent iNOS and proinflammatory cytokines production / Br. J. Pharmacol 154 : 165 ~ 173
[학술지(정기간행물)] - Peter, K. / 2013 / A novel concept for detoxification:complexation between aconitine and liquiritin in a Chinese herbal formula (‘Sini Tang’) / J. Ethnopharmacol 149 : 562 ~ 569
[학술지(정기간행물)] - Lee, J. Y. / 2009 / Liquiritigenin, a licorice flavonoid, helps mice resist disseminated candidiasis due to Candida albicans by Th1 immune response, whereas liquiritin, its glycoside form, does not / Int. Immunopharmacol 9 : 632 ~ 638
[학술지(정기간행물)] - Zhao, Z. / 2008 / Antidepressantlike effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats / Behav. Brain Res 194 : 108 ~ 113
[학술지(정기간행물)] - Kim, Y. W. / 2008 / Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-êB-dependent iNOS and proinflammatory cytokines production / Br. J. Pharmacol 154 : 165 ~ 173
[학술지(정기간행물)] - Peter, K. / 2013 / A novel concept for detoxification:complexation between aconitine and liquiritin in a Chinese herbal formula (‘Sini Tang’) / J. Ethnopharmacol 149 : 562 ~ 569
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UCI(KEPA) : I410-ECN-0101-2016-470-001849615