지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 230 - 238 (9page)
이용수
초록· 키워드
오류제보하기
Abnormal glycosylation can significantly affect the intrinsic functions (i.e., stability and solubility) of proteins and the extrinsic protein interactions with other biomolecules. For example, recombinant glycoprotein therapeutics needs proper glycosylation for optimal drug efficacy. Therefore, there has been a strong demand for rapid, sensitive and high-throughput glycomics tools for real-time monitoring and fast validation of the biotherapeutics glycosylation. Although liquid chromatography tandem mass spectrometry (LC-MS/MS) is one of the most powerful tools for the characterization of glycan structures, it is generally time consuming and requires highly skilled personnel to collect the data and analyze the results. Recently, as an alternative method, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-MS), which is a fast, robust and easy-to-use instrumentation, has been used for quantitative glycomics with various chemical derivatization techniques. In this review, we highlight the recent advances in MALDI-MS based quantitative glycan analysis according to the chemical derivatization strategies. Moreover, we address the application of MALDIMS for high-throughput glycan analysis in many fields of clinical and biochemical engineering.
목차
Abstract
1. INTRODUCTION
2. MALDI-MS 기반의 당쇄 정량 분석 방법
3. CONCLUSION
REFERENCES
참고문헌 (44)
참고문헌 신청
[학술지(정기간행물)] - Alvarez-Manilla, G. / 2007 / Tools for glycomics: Relative quantitation of glycans by isotopic permethylation using 13CH3I / Glycobiology 17 : 677 ~ 687
[학술지(정기간행물)] - Blom, N. / 2004 / Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence / Proteomics 4 : 1633 ~ 1649
[학술지(정기간행물)] - Chirino, A. J. / 2004 / Minimizing the immunogenicity of protein therapeutics / Drug Discov. Today 9 : 82 ~ 90
[학술지(정기간행물)] - Ciucanu, I. / 2003 / Elimination of oxidative degradation during the per-O-methylation of carbohydrates / J. Am. Chem. Soc 125 : 16213 ~ 16219
[학술지(정기간행물)] - Edelman, G. M. / 1983 / Cell adhesion molecules / Science 219 : 450 ~ 457
[학술지(정기간행물)] - Blom, N. / 2004 / Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence / Proteomics 4 : 1633 ~ 1649
[학술지(정기간행물)] - Chirino, A. J. / 2004 / Minimizing the immunogenicity of protein therapeutics / Drug Discov. Today 9 : 82 ~ 90
[학술지(정기간행물)] - Ciucanu, I. / 2003 / Elimination of oxidative degradation during the per-O-methylation of carbohydrates / J. Am. Chem. Soc 125 : 16213 ~ 16219
[학술지(정기간행물)] - Edelman, G. M. / 1983 / Cell adhesion molecules / Science 219 : 450 ~ 457
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UCI(KEPA) : I410-ECN-0101-2016-470-002024352