지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Purpose: The object of this study is to observe the anti-ulcerative effects of BK-1202 (IGM), a mixed herbal formula consisting of 9 herbal drugs, which have been traditional Korean medicine for treating various digestive diseases, on indomethacin-induced gastric ulcer in rat.
Methods: Three different doses of IGM extract (200, 100 and 50 mg/kg) were orally administered once 30 min before indomethacin treatment. Six hours after indomethacin treatment, changes in the gross lesion scores, fundic histopathology, MPO activity and antioxidant activities were observed. The results were compared with two reference groups treated with omeprazole (10 mg/kg), antioxidant and proton pump inhibitor, and DA-9601 (100 mg/kg), a standardized extract of the herb Artemisiaasiatica.
Results: In all three doses of IGM extract, significantly decreased gastric damages were observed in the indomethacin-induced gastric ulcer rats, when compared with the indomethacin-treated control rats. IGM extracts also strengthened the antioxidative defense systems, decreasing the level of lipid peroxidation and catalase activity while increasing the superoxide dismutase and glutathione contents. IGM extracts showed similar anti-ulcerative effects to those shown by equal dose of DA-9601, and the effects of 50 mg/kg IGM extracts were comparable to those of 10 mg/kg omeprazole.
Conclusion: The results obtained in this study suggest that IGM extract has favorable effects on the indomethacin-induced gastric damages by strengthening the antioxidative defense systems and enhancing anti-inflammatory effects.
Methods: Three different doses of IGM extract (200, 100 and 50 mg/kg) were orally administered once 30 min before indomethacin treatment. Six hours after indomethacin treatment, changes in the gross lesion scores, fundic histopathology, MPO activity and antioxidant activities were observed. The results were compared with two reference groups treated with omeprazole (10 mg/kg), antioxidant and proton pump inhibitor, and DA-9601 (100 mg/kg), a standardized extract of the herb Artemisiaasiatica.
Results: In all three doses of IGM extract, significantly decreased gastric damages were observed in the indomethacin-induced gastric ulcer rats, when compared with the indomethacin-treated control rats. IGM extracts also strengthened the antioxidative defense systems, decreasing the level of lipid peroxidation and catalase activity while increasing the superoxide dismutase and glutathione contents. IGM extracts showed similar anti-ulcerative effects to those shown by equal dose of DA-9601, and the effects of 50 mg/kg IGM extracts were comparable to those of 10 mg/kg omeprazole.
Conclusion: The results obtained in this study suggest that IGM extract has favorable effects on the indomethacin-induced gastric damages by strengthening the antioxidative defense systems and enhancing anti-inflammatory effects.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
References
참고문헌 (42)
참고문헌 신청
[학술지(정기간행물)] - D.R.Lim / 2006 / The effect of Scutellaria Radix on gastritis and gastric ulcer / J. Applied Phamacology 1 : 4 ~ 38
[학술지(정기간행물)] - 김상찬 / 2003 / 순기화중탕이 Indomethacin으로 유발된 위궤양에 미치는 영향 / 동의생리병리학회지 17 (2) : 326 ~ 337
[학술지(정기간행물)] - Hawkins C / 2000 / The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs:a review of the literature / J Pain Symptom Manage 20 (2) : 140 ~ 151
[학술지(정기간행물)] - Miederer SE / 1986 / Will anti-ulcer drugs differ only in their side effects Fortschr Med 104 (3) : 918 ~ 920
[단행본] - Heo J. / 2003 / Dongeui-Bogam / Bubin Publishers Co : 1155 ~
[학술지(정기간행물)] - 김상찬 / 2003 / 순기화중탕이 Indomethacin으로 유발된 위궤양에 미치는 영향 / 동의생리병리학회지 17 (2) : 326 ~ 337
[학술지(정기간행물)] - Hawkins C / 2000 / The gastroduodenal toxicity of nonsteroidal anti-inflammatory drugs:a review of the literature / J Pain Symptom Manage 20 (2) : 140 ~ 151
[학술지(정기간행물)] - Miederer SE / 1986 / Will anti-ulcer drugs differ only in their side effects Fortschr Med 104 (3) : 918 ~ 920
[단행본] - Heo J. / 2003 / Dongeui-Bogam / Bubin Publishers Co : 1155 ~
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UCI(KEPA) : I410-ECN-0101-2016-519-002648798