지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 406 - 411 (6page)
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초록· 키워드
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Background/Aims: DA-6034 has anti-inflammatory activities and exhibits cytoprotective effects in acute gastric injury models. However, explanations for the protective effects of DA-6034 on intestinal permeability are limited. This study sought to investigate the effect of DA-6034 on intestinal permeability in an indomethacin-induced small intestinal injury model and its protective effect against small intestinal injury.
Methods: Rats in the treatment group received DA-6034 from days 0 to 2 and indomethacin from days 1 to 2. Rats in the control group received indomethacin from days 1 to 2. On the fourth day, the small intestines were examined to compare the severity of inflammation. Intestinal permeability was evaluated by using fluorescein isothiocyanate-labeled dextran. Western blotting was performed to confirm the association between DA-6034 and the extracellular signal-regulated kinase (ERK) pathway. Results: The inflammation scores in the treatment group were lower than those in the control group, but the difference was statistically insignificant. Hemorrhagic lesions in the treatment group were broader than those in the control group, but the difference was statistically insignificant. Intestinal permeability was lower in the treatment group than in the control group. DA-6034 enhanced extracellular signal-regulated kinase expression, and intestinal permeability was negatively correlated with ERK expression.
Conclusions: DA-6034 may decrease intestinal permeability in an indomethacin-induced intestinal injury model via the ERK pathway.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Barbara G / 2012 / Mucosal permeability and immune activation as potential therapeutic targets of probiotics in irritable bowel syndrome / J Clin Gastroenterol 46:S52~S55
Gecse K / 2012 / Leaky gut in patients with diarrheapredominant irritable bowel syndrome and inactive ulcerative colitis / Digestion 85:40~46
Suenaert P / 2002 / Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease / Am J Gastroenterol 97:2000~2004
Thiéfin G / 2005 / Toxic effects of nonsteroidal antiinflammatory drugs on the small bowel, colon, and rectum / Joint Bone Spine 72:286~294
Sandek A / 2008 / The emerging role of the gut in chronic heart failure / Curr Opin Clin Nutr Metab Care 11:632~639
Gecse K / 2012 / Leaky gut in patients with diarrheapredominant irritable bowel syndrome and inactive ulcerative colitis / Digestion 85:40~46
Suenaert P / 2002 / Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease / Am J Gastroenterol 97:2000~2004
Thiéfin G / 2005 / Toxic effects of nonsteroidal antiinflammatory drugs on the small bowel, colon, and rectum / Joint Bone Spine 72:286~294
Sandek A / 2008 / The emerging role of the gut in chronic heart failure / Curr Opin Clin Nutr Metab Care 11:632~639
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