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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.30
- 발행연도
- 2015.12
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- 1 - 8 (8page)
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Objectives: In this study, the effect of tube length and outer diameter (OD) size of hydroxylated-multi walled carbon nanotubes (OH-MWCNTs) on their uptake and toxicity was investigated in the nematode Caenorhabditis elegans using a functional mutant analysis.
Methods: The physicochemical properties of three different OH-MWCNTs were characterized. Uptake and toxicity were subsequently investigated on C. elegans exposed to MWCNTs with different ODs and tube lengths.
Results: The results of mutant analysis suggest that ingestion is the main route of MWCNTs uptake. We found that OH-MWCNTs with smaller ODs were more toxic than those with larger ODs, and OH-MWCNTs with shorter tube lengths were more toxic than longer counterparts to C. elegans.
Conclusions: Overall the results suggest the aspect ratio affects the toxicity of MWCNTs in C. elegans. Further thorough study on the relationship between physicochemical properties and toxicity needs to be conducted for more comprehensive understanding of the uptake and toxicity of MWCNTs.
Methods: The physicochemical properties of three different OH-MWCNTs were characterized. Uptake and toxicity were subsequently investigated on C. elegans exposed to MWCNTs with different ODs and tube lengths.
Results: The results of mutant analysis suggest that ingestion is the main route of MWCNTs uptake. We found that OH-MWCNTs with smaller ODs were more toxic than those with larger ODs, and OH-MWCNTs with shorter tube lengths were more toxic than longer counterparts to C. elegans.
Conclusions: Overall the results suggest the aspect ratio affects the toxicity of MWCNTs in C. elegans. Further thorough study on the relationship between physicochemical properties and toxicity needs to be conducted for more comprehensive understanding of the uptake and toxicity of MWCNTs.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Lin Y. / 2004 / Advances toward bioapplications of carbon nanotubes / J Mate Chem 14 (4) : 527 ~ 541
[학술지(정기간행물)] - Bianco A / 2005 / Biomedical applications of functionalised carbon nanotubes / Chem Commun (Camb) (5) : 571 ~ 577
[학술지(정기간행물)] - Hu H. / 2004 / Chemically functionalized carbon nanotubes as substrates for neuronal growth / Nano Lett 4 (3) : 507 ~ 511
[학술지(정기간행물)] - Peer D. / 2007 / Nanocarriers as an emerging platform for cancer therapy / Nat Nanotechnol 2 (12) : 751 ~ 760
[학술지(정기간행물)] - Wu H / 2010 / Novel ultrafiltration membranes prepared from a multi-walled carbon nanotubes/polymer composite / J Memb Sci 362 (1-2) : 374 ~ 383
[학술지(정기간행물)] - Bianco A / 2005 / Biomedical applications of functionalised carbon nanotubes / Chem Commun (Camb) (5) : 571 ~ 577
[학술지(정기간행물)] - Hu H. / 2004 / Chemically functionalized carbon nanotubes as substrates for neuronal growth / Nano Lett 4 (3) : 507 ~ 511
[학술지(정기간행물)] - Peer D. / 2007 / Nanocarriers as an emerging platform for cancer therapy / Nat Nanotechnol 2 (12) : 751 ~ 760
[학술지(정기간행물)] - Wu H / 2010 / Novel ultrafiltration membranes prepared from a multi-walled carbon nanotubes/polymer composite / J Memb Sci 362 (1-2) : 374 ~ 383
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UCI(KEPA) : I410-ECN-0101-2017-539-000798791