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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 273 - 279 (7page)
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초록· 키워드
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Objectives: Carbon nanotubes (CNTs) are next-generation industrial nanoparticles which possess excellent mechanical strength along with good thermal conductivity and electric properties. Given these characteristics, carbon nanotubes are being widely applied in various fields, including research and development. However, concerns have been raised over hazardous properties due to their similar fiber shape to asbestos. Recent studies have shown that CNTs pose potential hazards which may cause fibrosis and/or lung inflammation similarly to asbestos.
Methods: After intratracheal instillation of SWCNTs and MWCNTs to rats, pulmonary surfactant (PS) of the SWCNTs and MWCNTs was measured and analyzed using bronchoalveolar lavage fluid collected from the lung. After a single intratracheal instillation of SWCNTs and MWCNTs, phospholipid predominantly showed a significant increase compared to the control group, while proteins exhibited a significant increase both three days and one week after instillation.
Results: As a result of surface tension, MWCNTs showed a significant decrease three days after treatment compared to the control group. In the case of the total cell number three days after instillation, MWCNTs revealed a temporarily significant increase when compared to the control group. For PMN number, when compared to the control group, SWCNTs displayed a significant increase throughout the observation period, while MWCNTs showed a significant increase three days and three months after treatment.
Conclusions: After exposure to CNTs, the total cell number and PNT number, which indicate inflammatory response, were significantly increased. Therefore, this study suggests fiber?shaped CNTs may have a harmful effect on the lungs.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Maynard AD / 2007 / Nanotechnology: the next big thing, or much ado about nothing? / Ann Occup Hyg 51:1~12
Oh KH / 2009 / Standardization trends and technologies for carbon nanotubes / JIES 12(4):20~25
Aiso S / 2010 / Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats / Ind Health 48:783~795
DeLorme MP / 2012 / Ninety-day inhalation toxicity study with a vapor grown carbon nanofiber in rats / Toxicol Sci 128:449~460
Ma-Hock / 2009 / Inhalation toxicity of multi-wall carbon nanotubes in rats exposed for three month / Toxicol Sci 112:468~481
Oh KH / 2009 / Standardization trends and technologies for carbon nanotubes / JIES 12(4):20~25
Aiso S / 2010 / Pulmonary toxicity of intratracheally instilled multiwall carbon nanotubes in male Fischer 344 rats / Ind Health 48:783~795
DeLorme MP / 2012 / Ninety-day inhalation toxicity study with a vapor grown carbon nanofiber in rats / Toxicol Sci 128:449~460
Ma-Hock / 2009 / Inhalation toxicity of multi-wall carbon nanotubes in rats exposed for three month / Toxicol Sci 112:468~481
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