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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 101 - 106 (6page)
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The epidermal growth factor receptor(EGFR) protein kinase signaling is an important pathway in cancer development and recently reported that EGFR and its kinase domain molecules are mutated in various of cancers including head and neck cancer. Functional deregulation of EGFR due to mutations in coding exons and copy number amplification is the most common event in cancers, especially among receptor tyrosine kinases(TK). We have analyzed Korean oral squamous cell carcinomas (OSCC) cell lines for mutations in EGFRTK. Exons encoding the hot-spot regions in the TK domain of EGFR (exons 17 to 23) were amplified by using polymerase chain reaction(PCR) and sequenced directly. EGFR expression was also analyzed in 8 OSCC cell lines using western blotting. Data analysis of the EGFR exons 17 to 23 coding sequences did not show any mutations in the 8 OSCC cell lines that were analyzed. The absence of mutations indicate that protein overexpression might be responsible for activation rather than mutation.
목차
Abstract
I. Introduction
II. Materials and Methods
III. Results
IV. Discussion
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Luka Milas / 2003 / Chemoradiotherapy: Emerging treatment improvement strategies / Head & Neck 25 (2) : 152 ~ 167
[학술지(정기간행물)] - C. J. Langer / 2012 / Exploring Biomarkers in Head and Neck Cancer / Cancer 118 (16) : 3882 ~ 3892
[학술지(정기간행물)] - E. S. Lampri / 2015 / Biomarkers of head and neck cancer, tools or a gordian knot? / Int J Clin Exp Med 8 (7) : 10340 ~ 10357
[학술지(정기간행물)] - S. P. D’Angelo / 2011 / Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas / J Clin Oncol 29 : 2066 ~ 2070
[학술지(정기간행물)] - A. F. Gazdar / 2009 / Activating and resistance mutations of EGFR in non-small-cell lung cancer : role in clinical response to EGFR tyrosine kinase inhibitors / Oncogene 28 : 24 ~ 31
[학술지(정기간행물)] - C. J. Langer / 2012 / Exploring Biomarkers in Head and Neck Cancer / Cancer 118 (16) : 3882 ~ 3892
[학술지(정기간행물)] - E. S. Lampri / 2015 / Biomarkers of head and neck cancer, tools or a gordian knot? / Int J Clin Exp Med 8 (7) : 10340 ~ 10357
[학술지(정기간행물)] - S. P. D’Angelo / 2011 / Incidence of EGFR exon 19 deletions and L858R in tumor specimens from men and cigarette smokers with lung adenocarcinomas / J Clin Oncol 29 : 2066 ~ 2070
[학술지(정기간행물)] - A. F. Gazdar / 2009 / Activating and resistance mutations of EGFR in non-small-cell lung cancer : role in clinical response to EGFR tyrosine kinase inhibitors / Oncogene 28 : 24 ~ 31
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UCI(KEPA) : I410-ECN-0101-2017-004-001405555