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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 261 - 270 (10page)
이용수
초록· 키워드
오류제보하기
The human immune system has evolved to fight against foreign pathogens. It plays a central role in the body’s defense mechanism. However, the immune memory geared to fight off a previously recognized pathogen, tends to remember an original form of the pathogen when a variant form subsequently invades. This has been termed ‘original antigenic sin’. This adverse immunological effect can alter vaccine effectiveness and sometimes cause enhanced pathogenicity or additional inflammatory responses, according to the type of pathogen and the circumstances of infection. Here we aim to give a simplified conceptual understanding of virus infection and original antigenic sin by comparing and contrasting the two examples of recurring infections such as influenza and dengue viruses in humans.
목차
ORIGINAL ANTIGENIC SIN
MECHANISM OF ORIGINAL ANTIGENIC SIN
ORIGINAL ANTIGENIC SIN AND VACCINE EFFICACY
ORIGINAL ANTIGENIC SIN AND INFLUENZA VIRUS IMMUNITY: ‘GOOD’ OAS?
CAN ‘BAD’ OAS PLAY A ROLE IN INFLUENZA VIRUS INFECTION?
ORIGINAL ANTIGENIC SIN AND DENGUE VIRUS INFECTION: CLASSIC ‘BAD’ OAS
CONCLUSION
REFERENCES
참고문헌 (62)
참고문헌 신청
[학술지(정기간행물)] - Davenport, F. M / 1953 / Epidemiologic and immunologic significance of age distribution of antibody to antigenic variants of influenza virus / J. Exp. Med 98 : 641 ~ 656
[학술지(정기간행물)] - Taylor, A / 2015 / Fc receptors in antibody-dependent enhancement of viral infections / Immunol. Rev 268 : 340 ~ 364
[학술지(정기간행물)] - McHeyzer-Williams, M / 2012 / Molecular programming of B cell memory / Nat. Rev .Immunol 12 : 24 ~ 34
[학술지(정기간행물)] - Netea, M. G / 2016 / Trained immunity: A program of innate immune memory in health and disease / Science 352 : aaf1098 ~
[학술지(정기간행물)] - Okhrimenko, A / 2014 / Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory / Proc. Natl. Acad. Sci. U. S. A 111 : 9229 ~ 9234
[학술지(정기간행물)] - Taylor, A / 2015 / Fc receptors in antibody-dependent enhancement of viral infections / Immunol. Rev 268 : 340 ~ 364
[학술지(정기간행물)] - McHeyzer-Williams, M / 2012 / Molecular programming of B cell memory / Nat. Rev .Immunol 12 : 24 ~ 34
[학술지(정기간행물)] - Netea, M. G / 2016 / Trained immunity: A program of innate immune memory in health and disease / Science 352 : aaf1098 ~
[학술지(정기간행물)] - Okhrimenko, A / 2014 / Human memory T cells from the bone marrow are resting and maintain long-lasting systemic memory / Proc. Natl. Acad. Sci. U. S. A 111 : 9229 ~ 9234
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UCI(KEPA) : I410-ECN-0101-2017-517-001663384