지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 281 - 285 (5page)
이용수
초록· 키워드
오류제보하기
CD4<SUP>+</SUP> regulatory T cells (Tregs) are essential for normal immune surveillance, and their dysfunction can lead to the development of autoimmune diseases, such as type-1 diabetes (T1D). T1D is a T cell-mediated autoimmune disease characterized by islet b cell destruction, hypoinsulinemia, and severely altered glucose homeostasis. Tregs play a critical role in the development of T1D and participate in peripheral tolerance. Pluripotent stem cells (PSCs) can be utilized to obtain a renewable source of healthy Tregs to treat T1D as they have the ability to produce almost all cell types in the body, including Tregs. However, the right conditions for the development of antigen (Ag)-specific Tregs from PSCs (i.e., PSC-Tregs) remain undefined, especially molecular mechanisms that direct differentiation of such Tregs. Auto Ag-specific PSC-Tregs can be programmed to be tissue-associated and infiltrate to local inflamed tissue (e.g., islets) to suppress autoimmune responses after adoptive transfer, thereby avoiding potential overall immunosuppression from non-specific Tregs. Developing auto Ag-specific PSC-Tregs can reduce overall immunosuppression after adoptive transfer by accumulating inflamed islets, which drives forward the use of therapeutic PSC-Tregs for cell-based therapies in T1D.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
[학술지(정기간행물)] - Bluestone, J. A / 2015 / Type 1diabetes immunotherapy using polyclonal regulatory T cells / Sci. Transl. Med 7 : 315ra189 ~
[학술지(정기간행물)] - Mahne, A. E / 2015 / Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes / J. Immunol 194 : 3147 ~ 3155
[학술지(정기간행물)] - Hossain, D. M / 2013 / FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells / Immunity 39 : 1057 ~ 1069
[학술지(정기간행물)] - Aschenbrenner, K / 2007 / Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells / Nat. Immunol 8 : 351 ~ 358
[학술지(정기간행물)] - Haque, R / 2010 / FoxP3and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development / Arthritis Res. Ther 12 : R66 ~
[학술지(정기간행물)] - Mahne, A. E / 2015 / Therapeutic regulatory T cells subvert effector T cell function in inflamed islets to halt autoimmune diabetes / J. Immunol 194 : 3147 ~ 3155
[학술지(정기간행물)] - Hossain, D. M / 2013 / FoxP3 acts as a cotranscription factor with STAT3 in tumor-induced regulatory T cells / Immunity 39 : 1057 ~ 1069
[학술지(정기간행물)] - Aschenbrenner, K / 2007 / Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells / Nat. Immunol 8 : 351 ~ 358
[학술지(정기간행물)] - Haque, R / 2010 / FoxP3and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development / Arthritis Res. Ther 12 : R66 ~
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UCI(KEPA) : I410-ECN-0101-2017-517-001663400