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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 578 - 585 (8page)
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초록· 키워드
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Background: Immunosuppression and age-related deficiencies in cell-mediated immunity are important factors for the reactivation of latent varicella-zoster virus (VZV).
CD4+CD25+Foxp3+ regulatory T (Treg) cells and T helper 17 (Th17) cells are closely associated with various viral infections. Objective: We analyzed Treg cells and Th17 cells in patients with herpes zoster and investigated their relationship with the reactivation of latent VZV. Methods: Treg and Th17 cells in peripheral blood and the ratio of Th17 to Treg cells were examined in patients with herpes zoster and healthy controls. Changes between pre-treatment and post-treatment estimates of Treg and Th17 cells and clinical parameters in patients with herpes zoster were also analyzed.
Results: The proportion of circulating Th17 cells and the Th17/Treg cell ratio were significantly higher in patients with herpes zoster than controls (p=0.012, 0.013), but there was no significant difference in the proportion of Treg cells between groups. There was no significant difference in the proportions of Treg and Th17 cells and the Th17/Treg cell ratio before and after treatment and between the non-postherpetic neuralgia and postherpetic neuralgia groups. Changes in Treg and Th17 cells and the Th17/Treg cell ratio were not significantly correlated with changes in the visual analog scale.
Body surface area was significantly correlated with Treg cells, Th17 cells, and the Th17/Treg cell ratio (p=0.022, 0.002, 0.004). Conclusion: An imbalance between Th17 and Treg cells is associated with the reactivation of VZV, which may contribute to pathogenesis of herpes zoster.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Arvin A / 2007 / Human herpesviruses: biology, therapy, and immunoprophylaxis / Cambridge University Press : 700 ~ 712
Chen Y / 2015 / Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection / Exp Ther Med 9 : 573 ~ 578
DuPage M / 2016 / Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease / Nat Rev Immunol 16 : 149 ~ 163
Falaki F / 2014 / The effect of low-level laser therapy on trigeminal neuralgia: a review of literature / J Dent Res Dent Clin Dent Prospects 8 : 1 ~ 5
Hao C / 2014 / Imbalance of regulatory T cells and T helper type 17 cells in patients with chronic hepatitis C / Immunology 143 : 531 ~ 538
Chen Y / 2015 / Effects of the Treg/Th17 cell balance and their associated cytokines in patients with hepatitis B infection / Exp Ther Med 9 : 573 ~ 578
DuPage M / 2016 / Harnessing the plasticity of CD4(+) T cells to treat immune-mediated disease / Nat Rev Immunol 16 : 149 ~ 163
Falaki F / 2014 / The effect of low-level laser therapy on trigeminal neuralgia: a review of literature / J Dent Res Dent Clin Dent Prospects 8 : 1 ~ 5
Hao C / 2014 / Imbalance of regulatory T cells and T helper type 17 cells in patients with chronic hepatitis C / Immunology 143 : 531 ~ 538
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