Differential Expression of Hox and Notch Genes in Larval and Adult Stages of Echinococcus granulosus

Ebrahim Saedi Dezaki; Mohammad Mehdi Yaghoobi; Elham Taheri; Pooya Ghaseminejad Almani; Farideh Tohidi; Bruno Gottstein; Majid Fasihi Harandi

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저자정보: Ebrahim Saedi Dezaki (Kerman University of Medical Sciences) Mohammad Mehdi Yaghoobi (Graduate University of Advanced Technology) Elham Taheri (Kerman University of Medical Sciences) Pooya Ghaseminejad Almani (Kerman University of Medical Sciences) Farideh Tohidi (Kerman University of Medical Sciences) Bruno Gottstein (Faculty of Medicine and Vetsuisse Faculty of the University of Bern) Majid Fasihi Harandi (Kerman University of Medical Sciences)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.54 No.5

발행연도: 2016.10

수록면: 653 - 658 (6page)

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This investigation aimed to evaluate the differential expression of HoxB7 and notch genes in different developmental stages of Echinococcus granulosus sensu stricto. The expression of HoxB7 gene was observed at all developmental stages. Nevertheless, significant fold differences in the expression level was documented in the juvenile worm with 3 or more proglottids, the germinal layer from infected sheep, and the adult worm from an experimentally infected dog. The notch gene was expressed at all developmental stages of E. granulosus; however, the fold difference was significantly increased at the microcysts in monophasic culture medium and the germinal layer of infected sheep in comparison with other stages. The findings demonstrated that the 2 aforementioned genes evaluated in the present study were differentially expressed at different developmental stages of the parasite and may contribute to some important biological processes of E. granulosus.

#Echinococcus granulosus #cystic echinococcosis #HoxB7 gene #notch gene #real-time PCR

참고문헌 (33)

참고문헌 신청

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