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지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.11
- 수록면
- 897 - 906 (10page)
이용수
초록· 키워드
오류제보하기
Objectives: Periodontitis is multifactorial disease mainly caused by microbial community. Recently, some research has been conducted to find other possible risk factors including stress hormones related to periodontitis. Psychological stress can affect the periodontal health by a variety of biological mechanisms. This study compared the stress hormone levels in healthy subjects and patients with periodontal disease using saliva in order to investigate the association between periodontitis and stress.
Methods: The human saliva was collected from 38 periodontally healthy individuals and 34 patients with chronic periodontitis under Institutional Review Board. Their age was 20-60 years (40.3 10.45). From these samples, determination of salivary levels of cortisol and Dehydroepiandrosterone (DHEA) performed by enzyme immunoassay kit (Salimetrics Europe, Suffolk, UK). The independent t-test and Mann-Whitney test for trend was applied using IBM SPSS statistics version 12.0 Program to analyze statistically significant differences.
Results: Salivary cortisol levels of periodontitis patients were higher than those levels of healthy subjects (P ＜ 0.001), while salivary DHEA levels of periodontitis patients were not significantly different (P = 0.431). Salivary cortisol/DHEA ratio of periodontitis patients was higher than those levels of healthy subjects (P ＜ 0.001).
Conclusions: Our study demonstrates the high levels of cortisol concentrations and cortisol/DHEA ratio in saliva of periodontitis patients than those of healthy subjects. Since cortisol levels and cortisol/DHEA ratio can be significant factors related to the severity of periodontal disease, our study would be helpful for early diagnosis and treatment of periodontal disease.
Methods: The human saliva was collected from 38 periodontally healthy individuals and 34 patients with chronic periodontitis under Institutional Review Board. Their age was 20-60 years (40.3 10.45). From these samples, determination of salivary levels of cortisol and Dehydroepiandrosterone (DHEA) performed by enzyme immunoassay kit (Salimetrics Europe, Suffolk, UK). The independent t-test and Mann-Whitney test for trend was applied using IBM SPSS statistics version 12.0 Program to analyze statistically significant differences.
Results: Salivary cortisol levels of periodontitis patients were higher than those levels of healthy subjects (P ＜ 0.001), while salivary DHEA levels of periodontitis patients were not significantly different (P = 0.431). Salivary cortisol/DHEA ratio of periodontitis patients was higher than those levels of healthy subjects (P ＜ 0.001).
Conclusions: Our study demonstrates the high levels of cortisol concentrations and cortisol/DHEA ratio in saliva of periodontitis patients than those of healthy subjects. Since cortisol levels and cortisol/DHEA ratio can be significant factors related to the severity of periodontal disease, our study would be helpful for early diagnosis and treatment of periodontal disease.
목차
ABSTRACT
Ⅰ. 서론
Ⅱ. 재료 및 방법
Ⅲ. 결과
Ⅳ. 고찰
참고문헌
참고문헌 (37)
참고문헌 신청
[학술지(정기간행물)] - Mesa, F. / 2014 / Catecholamine metabolites in urine, as chronic stress biomarkers, are associated with higher risk of chronic periodontitis in adults / J Periodontol 85 (12) : 1755 ~ 1762
[학술지(정기간행물)] - Page, R.C. / 1997 / The pathogenesis of human periodontitis: an introduction / Periodontol 2000 14 : 9 ~ 11
[학술지(정기간행물)] - Cronin, A. J. / 2008 / Who is at risk? Periodontal disease risk analysis made accessible for the general dental practitioner / Br Dent J 205 (3) : 131 ~ 137
[학술지(정기간행물)] - Lazarus, R. S / 1993 / From psychological stress to the emotions : a history of changing outlooks / Annu Rev Psychol 44 : 1 ~ 21
[학술지(정기간행물)] - Chrousos, G. P / 1995 / The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation / N Engl J Med 332 (20) : 1351 ~ 1362
[학술지(정기간행물)] - Page, R.C. / 1997 / The pathogenesis of human periodontitis: an introduction / Periodontol 2000 14 : 9 ~ 11
[학술지(정기간행물)] - Cronin, A. J. / 2008 / Who is at risk? Periodontal disease risk analysis made accessible for the general dental practitioner / Br Dent J 205 (3) : 131 ~ 137
[학술지(정기간행물)] - Lazarus, R. S / 1993 / From psychological stress to the emotions : a history of changing outlooks / Annu Rev Psychol 44 : 1 ~ 21
[학술지(정기간행물)] - Chrousos, G. P / 1995 / The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation / N Engl J Med 332 (20) : 1351 ~ 1362
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UCI(KEPA) : I410-ECN-0101-2017-515-001566639