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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 337 - 343 (7page)
이용수
초록· 키워드
오류제보하기
Inflammation, an innate immune response mediated by macrophages, forms the first line of defence to protect our body from the invasion of various pathogens. Although inflammation is a defensive response, chronic inflammation has been regarded as the major cause of many types of human diseases such as inflammatory/autoimmune diseases, cancers, neurological diseases, and cardiovascular diseases. Folate receptor (FR) is a cell surface glycosylphosphatidylinositol (GPI)-anchored glycoprotein, and its three isoforms, FR-a, FR-b, and FR-g, are found in humans. Interestingly, FRs are highly expressed on a variety of cells, including cancer cells and activated macrophages, whereas their expression on normal cells is undetectable, indicating that FR-targeting could be a good selective strategy for the diagnosis and therapeutic treatment of cancers and activated macrophage-mediated inflammatory diseases. Previous studies successfully showed FR-targeted imaging of many types of cancers in animal models as well as human patients. Recently, a number of emerging studies have found that activated macrophages, which are critical players for a variety of inflammatory diseases, highly express FRs, and selective targeting of these FR-positive activated macrophages is a good approach to diagnose and treat inflammatory diseases. In this review, we describe the characteristics and structure of FRs, and further discuss FR-targeted diagnostics and therapeutics of human diseases, in particular, activated macrophage-mediated inflammatory diseases.
목차
INTRODUCTION
CHARACTERISTICS OF FRs AND THEIR STRUC TURES
DISTRIBUTION OF FRs IN NORMAL AND PA THOGENIC CELLS
FR-targeted imaging and diagnostics of inflammatory diseases
FR-targeted immunotherapy of inflammatory diseases
Conclusions and perspectives
REFERENCES
참고문헌 (50)
참고문헌 신청
[학술지(정기간행물)] - Low, P. S / 2008 / Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases / Acc. Chem. Res 41 : 120 ~ 129
[학술지(정기간행물)] - Lu, J. Y / 1999 / Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug / J. Drug Target 7 : 43 ~ 53
[학술지(정기간행물)] - Antony, A. C / 1992 / The biological chemistry of folate receptors / Blood 79 : 2807 ~ 2820
[학술지(정기간행물)] - Salazar, M. D / 2007 / The folate receptor:what does it promise in tissue-targeted therapeutics? / Cancer Metastasis Rev 26 : 141 ~ 152
[학술지(정기간행물)] - Elnakat, H / 2004 / Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy / Adv. Drug Deliv. Rev 56 : 1067 ~ 1084
[학술지(정기간행물)] - Lu, J. Y / 1999 / Folate-targeted enzyme prodrug cancer therapy utilizing penicillin-V amidase and a doxorubicin prodrug / J. Drug Target 7 : 43 ~ 53
[학술지(정기간행물)] - Antony, A. C / 1992 / The biological chemistry of folate receptors / Blood 79 : 2807 ~ 2820
[학술지(정기간행물)] - Salazar, M. D / 2007 / The folate receptor:what does it promise in tissue-targeted therapeutics? / Cancer Metastasis Rev 26 : 141 ~ 152
[학술지(정기간행물)] - Elnakat, H / 2004 / Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy / Adv. Drug Deliv. Rev 56 : 1067 ~ 1084
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UCI(KEPA) : I410-ECN-0101-2017-517-001848972