지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 220 - 226 (7page)
이용수
초록· 키워드
오류제보하기
Hypertriglyceridemia induces atherosclerosis and accordingly is a major causative factor in cardiovascular diseases. Macrophages that develop into foam cells are a crucial component in the development of atherosclerosis. Monocytes can be differentiated into M1 or M2 macrophages. M1 macrophages promote inflammatory responses, whereas M2 macrophages exhibit anti-inflammatory activity. Recently, we found that triglyceride (TG)-treated THP-1 monocytes express a variety of macrophage-specific surface markers, indicating that TG treatment could trigger the differentiation of monocytes into macrophages. In this study, we investigated whether TG-induced macrophages express the M1 or the M2 macrophage phenotype. THP-1 cells were treated with various concentrations of TG for different times and the expression of M1- and M2-specific markers was evaluated by RT-PCR. We found increased expression of M1 markers (CD40, CD80, and CD86) in TG-treated THP-1 cells in a TG dose- and time-dependent manner. The expression of M2 markers (CD163, CD200R, and CD206) showed variable responses to TG treatment. Taken together, our results indicate that TG treatment triggers the differentiation of monocytes into M1 macrophages, rather than into M2 macrophages, suggesting that TG contributes to pro-inflammatory responses.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (19)
참고문헌 신청
[학술지(정기간행물)] - Afford SC / 1999 / CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection / J Exp Med 189 : 441 ~ 446
[학술지(정기간행물)] - Covarrubias A / 2013 / ROS sets the stage for macrophage differentiation / Cell Research 23 : 984 ~ 985
[학술지(정기간행물)] - Dopheide JF / 2007 / Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro / Coron Artery Dis 18 : 523 ~ 531
[학술지(정기간행물)] - Elmetwali T / 2010 / CD40 ligand-induced carcinoma cell death: a balance between activation of TNFRassociated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals / J Immunol 184 : 1111 ~ 1120
[학술지(정기간행물)] - Fadini GP / 2014 / Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis / Atherosclerosis 237 : 805 ~ 808
[학술지(정기간행물)] - Covarrubias A / 2013 / ROS sets the stage for macrophage differentiation / Cell Research 23 : 984 ~ 985
[학술지(정기간행물)] - Dopheide JF / 2007 / Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro / Coron Artery Dis 18 : 523 ~ 531
[학술지(정기간행물)] - Elmetwali T / 2010 / CD40 ligand-induced carcinoma cell death: a balance between activation of TNFRassociated factor (TRAF) 3-dependent death signals and suppression of TRAF6-dependent survival signals / J Immunol 184 : 1111 ~ 1120
[학술지(정기간행물)] - Fadini GP / 2014 / Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis / Atherosclerosis 237 : 805 ~ 808
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UCI(KEPA) : I410-ECN-0101-2017-510-002026453