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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국독성학회 Toxicological Research Toxicological Research Vol.33 No.1
발행연도
2017.1
수록면
7 - 14 (8page)

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이 논문의 연구 히스토리 (5)

2018

Twenty-Eight-Day Repeated Inhalation Toxicity Study of Aluminum Oxide Nanoparticles in Male Sprague-Dawley Rats
Yong-Soon Kim ,  Yong-Hyun Chung ,  Dong-Seok Seo 외 2명 Toxicological Research 2018.10 학술저널

2017

Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats
Yong-Soon Kim ,  Cheol-Hong Lim ,  Seo-Ho Shin 외 1명 Toxicological Research 2017.06 학술저널
Effects of Didecyldimethylammonium Chloride (DDAC) on Sprague-Dawley Rats after 13 Weeks of Inhalation Exposure
Yong-Soon Kim ,  Sung-Bae Lee ,  Cheol-Hong Lim Toxicological Research 2017.01 학술저널

2015

Effects of Didecyldimethylammonium Chloride (DDAC) on Sprague-Dawley Rats by 13-weeks of Inhalation Exposure
Yong-Soon Kim ,  Cheol-Hong Lim 환경독성보건학회 심포지엄 및 학술대회 2015.06 학술대회자료
Acute Inhalation Toxicity Study of Furan in Sprague-Dawley Rats
Yong-Soon Kim 환경독성보건학회 심포지엄 및 학술대회 2015.06 학술대회자료

초록· 키워드

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Didecyldimethylammonium chloride (DDAC) is used in many types of biocidal products including tableware, carpets, humidifiers, and swimming pools, etc. In spite of increased chances of DDAC exposure through inhalation, studies on the inhalation toxicity of DDAC are not common even though the toxicity of DDAC might be significantly higher if it were to be administered through routes other than the respiratory system. DDAC aerosols were exposed to Sprague-Dawley rats in whole body exposure chambers for a duration of 13 weeks. The Mass Median Aerodynamic Diameters of the DDAC aerosol were 0.63 μm, 0.81 μm, and 1.65 μm, and the geometric standard deviations were 1.62, 1.65, and 1.65 in the low (0.11 ± 0.06 mg/㎥), the middle (0.36 ± 0.20 mg/㎥) and the high (1.41 ± 0.71 mg/㎥) exposure groups, respectively. Body weight was confirmed to be clearly influenced by exposure to DDAC and mean body weight was approximately 35% lower in the high (1.41 ± 0.71 mg/㎥) male group and 15% lower in the high (1.41 ± 0.71 mg/㎥) female group compared to that of the control group. In the bronchoalveolar lavage fluid assay, the levels of albumin and lactate dehydrogenase had no effect on DDAC exposure. The lung weight increased for the middle (0.36 ± 0.20 mg/㎥) and the high (1.41 ± 0.71 mg/m3) concentrations of the DDAC exposure group, and inflammatory cell infiltration and interstitial pneumonia were partially observed in the lungs of the middle (0.36 ± 0.20 mg/㎥) and the high (1.41 ± 0.71 mg/㎥) exposure groups. However, severe histopathological symptoms, including proteinosis and/or fibrosis, were not found. Based on the results of the changes in the body weight and lung weight, it is considered that the NOAEL (no-observed adverse effect) level for the 13-week exposure duration is 0.11 mg/㎥.
#Biocide #Didecyldimethylammonium chloride #Inhalation #Sub-chronic

목차

INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES

참고문헌 (13)

참고문헌 신청
Ohnuma, A / 2010 / Didecylmethylammonium chloride induces pulmonary inflammation and fibrosis in mice / Exp. Toxicol. Pathol 62:643~651 google schola United States Environmental Protection Agency / 2006 / Reregistration Eligibility Decision for Aliphatic Alkyl Quaternaries (DDAC) google schola Kim, K. W / 2014 / Humidifier disinfectantassociated children’s interstitial lung disease / Am. J. Respir. Crit. Care Med 189:48~56 google schola Yang, H. J / 2013 / Inhalation toxicity of humidifier disinfectants as a risk factor of children’s interstitial lung disease in Korea: a case-control study / PLoS One 8:e64430 google schola Wikipedia / Biocide google schola

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