지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 79 - 96 (18page)
이용수
초록· 키워드
오류제보하기
A variety of xenobiotic chemicals, such as polycyclic aromatic hydrocarbons (PAHs), aryl- and heterocyclic amines and tobacco related nitrosamines, are ubiquitous environmental carcinogens and are required to be activated to chemically reactive metabolites by xenobiotic-metabolizing enzymes, including cytochrome P450 (P450 or CYP), in order to initiate cell transformation. Of various human P450 enzymes determined to date, CYP1A1, 1A2, 1B1, 2A13, 2A6, 2E1, and 3A4 are reported to play critical roles in the bioactivation of these carcinogenic chemicals. In vivo studies have shown that disruption of Cyp1b1 and Cyp2a5 genes in mice resulted in suppression of tumor formation caused by 7,12-dimethylbenz[a]anthracene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, respectively. In addition, specific inhibitors for CYP1 and 2A enzymes are able to suppress tumor formation caused by several carcinogens in experimental animals in vivo, when these inhibitors are applied before or just after the administration of carcinogens. In this review, we describe recent progress, including our own studies done during past decade, on the nature of inhibitors of human CYP1 and CYP2A enzymes that have been shown to activate carcinogenic PAHs and tobacco-related nitrosamines, respectively, in humans. The inhibitors considered here include a variety of carcinogenic and/or non-carcinogenic PAHs and acethylenic PAHs, many flavonoid derivatives, derivatives of naphthalene, phenanthrene, biphenyl, and pyrene and chemopreventive organoselenium compounds, such as benzyl selenocyanate and benzyl selenocyanate; o-XSC, 1,2-, 1,3-, and 1,4-phenylenebis(methylene)selenocyanate.
목차
INTRODUCTION
CONCLUSIONS
REFERENCES
참고문헌 (24)
참고문헌 신청
Rendic, S / 2012 / Contributions of human enzymes in carcinogen metabolism / Chem. Res. Toxicol 25:1316~1383
Guengerich, F.P / 1988 / Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy / Cancer Res 48:2946~2954
Pelkonen, O / 1982 / Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis / Pharmacol. Rev 34:189~222
Jalas, J.R / 2005 / Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen / Chem. Res. Toxicol 18:95~110
Xue, W / 2005 / Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review / Toxicol. Appl. Pharmacol 206:73~93
Guengerich, F.P / 1988 / Roles of cytochrome P-450 enzymes in chemical carcinogenesis and cancer chemotherapy / Cancer Res 48:2946~2954
Pelkonen, O / 1982 / Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis / Pharmacol. Rev 34:189~222
Jalas, J.R / 2005 / Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen / Chem. Res. Toxicol 18:95~110
Xue, W / 2005 / Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review / Toxicol. Appl. Pharmacol 206:73~93
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UCI(KEPA) : I410-ECN-0101-2017-513-002410005