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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.22 No.1
- 발행연도
- 2017.3
- 수록면
- 9 - 15 (7page)
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Vaccinium angustifolium, commonly known as the lowbush blueberry, is a rich source of flavonoids, with which various human physiological activities have been associated. The present study focuses on the investigation of the effect of the methanolic extract of V. angustifolium root extract (VAE) on high affinity immunoglobulin E receptor (FcεRI) α chain antibody (CRA-1)-induced allergic reaction in human basophilic KU812F cells. The total phenolic content of VAE was found to be 170±1.9 mg gallic acid equivalents/g. Flow cytometry analysis revealed that the cell surface expression of FcεRI was suppressed in a concentration-dependent manner upon culture with VAE. Reverse-transcriptase polymerase chain reaction analysis showed that the mRNA level of the FcεRI α chain was reduced in a concentration-dependent manner as a result of VAE treatment. Western blot analysis revealed that the protein expression of FcεRI and the phosphorylation of extracellular signal-regulated kinases (ERK) 1/2 were concentration-dependently inhibited by VAE. We determined that VAE inhibited anti-CRA-1-induced histamine release, in addition to the elevation of intracellular calcium concentration ([Ca<SUP>2+</SUP>]i), in a concentration-dependent manner. These results indicate that VAE may exert an anti-allergic effect via the inhibition of calcium influx and histamine release, which occurs as a result of the down-regulation of FcεRI expression through inhibition of ERK 1/2 activation.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (36)
참고문헌 신청
[학술지(정기간행물)] - Bomser J / 1996 / In vitro anticancer activity of fruit extracts from Vaccinium species / Planta Med 62 : 212 ~ 216
[학술지(정기간행물)] - Del Bo’ C / 2015 / Anthocyanins and phenolic acids from a wild blueberry(Vaccinium angustifolium)powder counteract lipid accumulation in THP-1-derived macrophages / Eur J Nutr 55 : 171 ~ 182
[학술지(정기간행물)] - Esposito D / 2014 / Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro / J Agric Food Chem 62 : 7022 ~ 7028
[학술지(정기간행물)] - Del Bo’ C / 2016 / Different effects of anthocyanins and phenolic acids from wild blueberry(Vaccinium angustifolium)on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment / Mol Nutr Food Res 60 : 2355 ~ 2366
[학술지(정기간행물)] - Joseph JA / 2006 / Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes / J Alzheimers Dis 9 : 35 ~ 42
[학술지(정기간행물)] - Del Bo’ C / 2015 / Anthocyanins and phenolic acids from a wild blueberry(Vaccinium angustifolium)powder counteract lipid accumulation in THP-1-derived macrophages / Eur J Nutr 55 : 171 ~ 182
[학술지(정기간행물)] - Esposito D / 2014 / Inhibitory effects of wild blueberry anthocyanins and other flavonoids on biomarkers of acute and chronic inflammation in vitro / J Agric Food Chem 62 : 7022 ~ 7028
[학술지(정기간행물)] - Del Bo’ C / 2016 / Different effects of anthocyanins and phenolic acids from wild blueberry(Vaccinium angustifolium)on monocytes adhesion to endothelial cells in a TNF-α stimulated proinflammatory environment / Mol Nutr Food Res 60 : 2355 ~ 2366
[학술지(정기간행물)] - Joseph JA / 2006 / Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes / J Alzheimers Dis 9 : 35 ~ 42
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UCI(KEPA) : I410-ECN-0101-2017-594-002407583