지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.93 No.1
- 발행연도
- 2017.7
- 수록면
- 18 - 26 (9page)
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초록· 키워드
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Purpose: To evaluate whether the Breast Imaging Reporting and Data System (BI-RADS) MRI lexicon could reflect the genomic information of breast cancers and to suggest intuitive imaging features as biomarkers.
Methods: Matched breast MRI data from The Cancer Imaging Archive and gene expression profile from The Cancer Genome Atlas of 70 invasive breast cancers were analyzed. Magnetic resonance images were reviewed according to the BIRADS MRI lexicon of mass morphology. The cancers were divided into 2 groups of gene clustering by gene set enrichment analysis. Clinicopathologic and imaging characteristics were compared between the 2 groups.
Results: The luminal subtype was predominant in the group 1 gene set and the triple-negative subtype was predominant in the group 2 gene set (55 of 56, 98.2% vs. 9 of 14, 64.3%). Internal enhancement descriptors were different between the 2 groups; heterogeneity was most frequent in group 1 (27 of 56, 48.2%) and rim enhancement was dominant in group 2 (10 of 14, 71.4%). In group 1, the gene sets related to mammary gland development were overexpressed whereas the gene sets related to mitotic cell division were overexpressed in group 2.
Conclusion: We identified intuitive imaging features of breast MRI associated with distinct gene expression profiles using the standard imaging variables of BI-RADS. The internal enhancement pattern on MRI might reflect specific gene expression profiles of breast cancers, which can be recognized by visual distinction.
Methods: Matched breast MRI data from The Cancer Imaging Archive and gene expression profile from The Cancer Genome Atlas of 70 invasive breast cancers were analyzed. Magnetic resonance images were reviewed according to the BIRADS MRI lexicon of mass morphology. The cancers were divided into 2 groups of gene clustering by gene set enrichment analysis. Clinicopathologic and imaging characteristics were compared between the 2 groups.
Results: The luminal subtype was predominant in the group 1 gene set and the triple-negative subtype was predominant in the group 2 gene set (55 of 56, 98.2% vs. 9 of 14, 64.3%). Internal enhancement descriptors were different between the 2 groups; heterogeneity was most frequent in group 1 (27 of 56, 48.2%) and rim enhancement was dominant in group 2 (10 of 14, 71.4%). In group 1, the gene sets related to mammary gland development were overexpressed whereas the gene sets related to mitotic cell division were overexpressed in group 2.
Conclusion: We identified intuitive imaging features of breast MRI associated with distinct gene expression profiles using the standard imaging variables of BI-RADS. The internal enhancement pattern on MRI might reflect specific gene expression profiles of breast cancers, which can be recognized by visual distinction.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - Voduc KD / 2010 / Breast cancer subtypes and the risk of local and regional relapse / J Clin Oncol 28 : 1684 ~ 1691
[학술지(정기간행물)] - Trop I / 2014 / Molecular classification of infiltrating breast cancer : toward personalized therapy / Radiographics 34 : 1178 ~ 1195
[학술지(정기간행물)] - Hyosun Kim / 2016 / Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma / 대한외과학회지 90 (1) : 1 ~ 9
[학술지(정기간행물)] - Uematsu T / 2009 / Triplenegative breast cancer : correlation between MR imaging and pathologic findings / Radiology 250 : 638 ~ 647
[학술지(정기간행물)] - Loo CE / 2011 / Magnetic resonance imaging response monitoring of breast cancer during neoadjuvant chemotherapy : relevance of breast cancer subtype / J Clin Oncol 29 : 660 ~ 666
[학술지(정기간행물)] - Trop I / 2014 / Molecular classification of infiltrating breast cancer : toward personalized therapy / Radiographics 34 : 1178 ~ 1195
[학술지(정기간행물)] - Hyosun Kim / 2016 / Biologic subtype is a more important prognostic factor than nodal involvement in patients with stages I and II breast carcinoma / 대한외과학회지 90 (1) : 1 ~ 9
[학술지(정기간행물)] - Uematsu T / 2009 / Triplenegative breast cancer : correlation between MR imaging and pathologic findings / Radiology 250 : 638 ~ 647
[학술지(정기간행물)] - Loo CE / 2011 / Magnetic resonance imaging response monitoring of breast cancer during neoadjuvant chemotherapy : relevance of breast cancer subtype / J Clin Oncol 29 : 660 ~ 666
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UCI(KEPA) : I410-ECN-0101-2018-514-000991875