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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.8
- 수록면
- 220 - 225 (6page)
- DOI
- 10.15188/kjopp.2017.08.31.4.220
이용수
초록· 키워드
오류제보하기
Lithospermi Radix (LR) is known to have an anti-inflammatory effect. However, the mechanisms are not well known. In this study, LPS-induced mouse RAW 264.7 macrophage cells were treated with LR to investigate the time-dependent inflammation response of LR. RAW 264.7 cells were treated with various concentrations of LR for 24 hours, followed by MTS assay. Cell viability was increased at all experimental concentrations. The mRNA expression levels of IL-1β, TNF-α and iNOS were increased by treatment of RAW 264.7 cells with LR at a concentration of 200 μ g/ml for 6 hours and 24 hours. Treatment of LR with 200 μg/ml concentration for 6 hours promoted mRNA expression levels of IL-1β, TNF-α and iNOS in LPS-induced RAW 264.7 cells. However, IL-1β, TNF-α and iNOS mRNA expression was suppressed by treatment of LR with 200 μg/ml concentration for 24 hours in LPS-induced RAW 264.7 cells. These results suggest that the effect on inflammation of LR is promptly promoted and then to rapidly alleviate the inflammatory reaction. This study proposes that the time-dependent activities of herbal medicine is a very important factor in analyzing the anti-inflammatory effect of various herbal medicines including LR.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (23)
참고문헌 신청
[기타자료] - Korea Food and Drug Administration. / 2015 / The Korean Pharmacopoeia Eleventh Edition / Korea Food and Drug Administration : 91 ~ 92
[기타자료] - Ministry of Health, Labour and Welfare / 2001 / The Japanese Pharmacopoeia, Fourteenth Edition / Hirokawa Shoten : 493 ~ 503
[단행본] - State Administration of Traditional chiense medicine of the People's Republic of China / 1999 / Zhonghuabencao / Shanghai Scientific and Technical Publishers : 525 ~ 531
[학술지(정기간행물)] - Chung HS / 2005 / Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages / J Ethnopharmacology 102 (3) : 412 ~ 417
[학술지(정기간행물)] - Kim SH / 2001 / Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33 / Cancer Lett 172 (2) : 171 ~ 175
[기타자료] - Ministry of Health, Labour and Welfare / 2001 / The Japanese Pharmacopoeia, Fourteenth Edition / Hirokawa Shoten : 493 ~ 503
[단행본] - State Administration of Traditional chiense medicine of the People's Republic of China / 1999 / Zhonghuabencao / Shanghai Scientific and Technical Publishers : 525 ~ 531
[학술지(정기간행물)] - Chung HS / 2005 / Inhibition of lipopolysaccharide and interferon-gamma-induced expression of inducible nitric oxide synthase and tumor necrosis factor-alpha by Lithospermi radix in mouse peritoneal macrophages / J Ethnopharmacology 102 (3) : 412 ~ 417
[학술지(정기간행물)] - Kim SH / 2001 / Antitumor activities of a newly synthesized shikonin derivative, 2-hyim-DMNQ-S-33 / Cancer Lett 172 (2) : 171 ~ 175
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UCI(KEPA) : I410-ECN-0101-2018-519-001251388