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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 382 - 394 (13page)
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초록· 키워드
오류제보하기
Background: Ginsenosides are the characteristic and principal components which manifest a variety of the biological and pharmacological activities of the roots and rhizomes of Panax ginseng (GRR). This study was carried out to qualitatively and quantitatively determine the ginsenosides in the cultivated and forest GRR.
Methods: A rapid and sensitive ultra-high-performance liquid chromatography coupled with diode-array detector and quadrupole/time of flight tandem mass spectrometry (UPLC-DAD-QTOF-MS/MS) was applied to the qualitative analysis of ginsenosides and a 4000 QTRAP triple quadrupole tandem mass spectrometer (HPLC-ESI-MS) was applied to quantitative analysis of 19 ginsenosides.
Results: In the qualitative analysis, all ingredients were separated in 10 min. A total of 131 ginsenosides were detected in cultivated and forest GRR. The method for the quantitative determination was validated for linearity, precision, and limits of detection and quantification. 19 representative ginsenosides were quantitated. The total content of all 19 ginsenosides in the forest GRR were much higher than those in the cultivated GRR, and were increased with the growing ages.
Conclusion: This newly developed analysis method could be applied to the quality assessment of GRR as well as the distinction between cultivated and forest GRR.
Methods: A rapid and sensitive ultra-high-performance liquid chromatography coupled with diode-array detector and quadrupole/time of flight tandem mass spectrometry (UPLC-DAD-QTOF-MS/MS) was applied to the qualitative analysis of ginsenosides and a 4000 QTRAP triple quadrupole tandem mass spectrometer (HPLC-ESI-MS) was applied to quantitative analysis of 19 ginsenosides.
Results: In the qualitative analysis, all ingredients were separated in 10 min. A total of 131 ginsenosides were detected in cultivated and forest GRR. The method for the quantitative determination was validated for linearity, precision, and limits of detection and quantification. 19 representative ginsenosides were quantitated. The total content of all 19 ginsenosides in the forest GRR were much higher than those in the cultivated GRR, and were increased with the growing ages.
Conclusion: This newly developed analysis method could be applied to the quality assessment of GRR as well as the distinction between cultivated and forest GRR.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
References
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Akerele O / 1992 / WHO guideline for assessment of herbal medicines / Fitoterapia 63 : 99 ~ 104
[학술지(정기간행물)] - Yang XB / 2013 / Study on ginsenosides in the roots and rhizomes of Panax ginseng / Mod Chin Med 15 : 349 ~ 358
[학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
[학술지(정기간행물)] - Park JD / 2005 / Biological activities and chemistry of saponins from Panax ginseng C.A. Meyer / Phytochem Reviews 4 : 159 ~ 175
[학술지(정기간행물)] - Ru WW / 2015 / Chemical constituents and bioactivities of Panax ginseng (C.A. Mey.) / Drug Discov Ther 9 : 23 ~ 32
[학술지(정기간행물)] - Yang XB / 2013 / Study on ginsenosides in the roots and rhizomes of Panax ginseng / Mod Chin Med 15 : 349 ~ 358
[학술지(정기간행물)] - Attele AS / 1999 / Ginseng pharmacology: multiple constituents and multiple actions / Biochem Pharmacol 58 : 1685 ~ 1693
[학술지(정기간행물)] - Park JD / 2005 / Biological activities and chemistry of saponins from Panax ginseng C.A. Meyer / Phytochem Reviews 4 : 159 ~ 175
[학술지(정기간행물)] - Ru WW / 2015 / Chemical constituents and bioactivities of Panax ginseng (C.A. Mey.) / Drug Discov Ther 9 : 23 ~ 32
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