지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.7
- 수록면
- 611 - 618 (8page)
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초록· 키워드
오류제보하기
Background: It is well recognized that gut microbiota is involved in the biotransformation of ginsenosides by converting the polar ginsenosides to nonpolar bioactive ginsenosides. However, the roles of the gut microbiota on the pharmacokinetics of ginsenosides in humans have not yet been fully elucidated.
Methods: Red ginseng (RG) or fermented red ginseng was orally administered to 34 healthy Korean volunteers, and the serum concentrations of the ginsenosides were determined using liquid chromatography-tandem mass spectrometry. In addition, the fecal ginsenoside Rd- and compound K (CK)-forming activities were measured. Then, the correlations between the pharmacokinetic profiles of the ginsenosides and the fecal ginsenoside-metabolizing activities were investigated.
Results: For the RG group, the area under the serum concentration-time curve values of ginsenosides Rd, F2, Rg3, and CK were 8.20 ± 11.95 ng · h/mL, 4.54±3.70 ng · h/mL, 36.40± 19.68 ng · h/mL, and 40.30± 29.83 ng · h/mL, respectively. For the fermented red ginseng group, the the area under curve from zero to infinity (AUCN) values of ginsenosides Rd, F2, Rg3, and CK were 187.90± 95.87 ng · h/mL, 30.24±41.87 ng · h/mL, 28.68±14.27 ng · h/mL, and 137.01±96.16 ng · h/mL, respectively. The fecal CK-forming activities of the healthy volunteers were generally proportional to their ginsenoside Rd-forming activities. The area under the serum concentration-time curve value of CK exhibited an obvious positive correlation (r= 0.566, p < 0.01) with the fecal CK-forming activity.
Conclusion: The gut microbiota may play an important role in the bioavailability of the nonpolar RG ginsenosides by affecting the biotransformation of the ginsenosides.
Methods: Red ginseng (RG) or fermented red ginseng was orally administered to 34 healthy Korean volunteers, and the serum concentrations of the ginsenosides were determined using liquid chromatography-tandem mass spectrometry. In addition, the fecal ginsenoside Rd- and compound K (CK)-forming activities were measured. Then, the correlations between the pharmacokinetic profiles of the ginsenosides and the fecal ginsenoside-metabolizing activities were investigated.
Results: For the RG group, the area under the serum concentration-time curve values of ginsenosides Rd, F2, Rg3, and CK were 8.20 ± 11.95 ng · h/mL, 4.54±3.70 ng · h/mL, 36.40± 19.68 ng · h/mL, and 40.30± 29.83 ng · h/mL, respectively. For the fermented red ginseng group, the the area under curve from zero to infinity (AUCN) values of ginsenosides Rd, F2, Rg3, and CK were 187.90± 95.87 ng · h/mL, 30.24±41.87 ng · h/mL, 28.68±14.27 ng · h/mL, and 137.01±96.16 ng · h/mL, respectively. The fecal CK-forming activities of the healthy volunteers were generally proportional to their ginsenoside Rd-forming activities. The area under the serum concentration-time curve value of CK exhibited an obvious positive correlation (r= 0.566, p < 0.01) with the fecal CK-forming activity.
Conclusion: The gut microbiota may play an important role in the bioavailability of the nonpolar RG ginsenosides by affecting the biotransformation of the ginsenosides.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results and discussion
4. Conclusion
References
참고문헌 (44)
참고문헌 신청
Christensen LP / 2009 / Ginsenosides chemistry, biosynthesis, analysis, and potential health effects / Adv Food Nutr Res 55:1~99
Ki Hyun Kim / 2018 / Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions / Journal of Ginseng Research 42(3):239~247
Li CP / 1973 / An introductory note to ginseng / Am J Chin Med 1:249~261
Kasai R / 1983 / Saponins of red ginseng / Chem Pharm Bull 31:2120~2125
이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39(4):384~391
Ki Hyun Kim / 2018 / Beneficial effects of Panax ginseng for the treatment and prevention of neurodegenerative diseases: past findings and future directions / Journal of Ginseng Research 42(3):239~247
Li CP / 1973 / An introductory note to ginseng / Am J Chin Med 1:249~261
Kasai R / 1983 / Saponins of red ginseng / Chem Pharm Bull 31:2120~2125
이상명 / 2015 / Characterization of Korean Red Ginseng (Panax ginseng Meyer): History, preparation method, and chemical composition / Journal of Ginseng Research 39(4):384~391
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UCI(KEPA) : I410-ECN-0101-2020-524-000843235