지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 477 - 486 (10page)
이용수
초록· 키워드
오류제보하기
Background: Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA(miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be antiangiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).
Methods and Results: Combining in vitro and in vivo data, KGE at 500 mg/mL was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR.
Conclusion: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.
Methods and Results: Combining in vitro and in vivo data, KGE at 500 mg/mL was found to induce angiogenesis. According to the miRNA sequencing, 484 differentially expressed miRNAs were found to be affected by KGE. Among them, angiogenic-related miRNAs; miR-15b, -23a, -214, and -377 were suppressed by KGE. Meanwhile, their corresponding angiogenic proteins were stimulated, including vascular endothelial growth factor, vascular endothelial growth factor receptor-2, endothelial nitric oxide synthase, and MET transmembrane tyrosine kinase. The miRNAs-regulated signaling pathways of KGE were then found by Cignal 45-Pathway Reporter Array, proving that KGE could activate GR.
Conclusion: KGE was found capable of inducing angiogenesis both in vivo and in vitro models through activating GR. This study provides a valuable insight into the angiogenic mechanisms depicted by KGE in relation to specific miRNAs.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Further perspective
References
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Heinke J / 2012 / Life is a pattern : vascular assembly within the embryo / Front Biosci (Elite Ed) 4 : 2269 ~ 2288
[학술지(정기간행물)] - Li WW / 2005 / The role of therapeutic angiogenesis in tissue repair and regeneration / Adv Skin Wound Care 18 : 491 ~ 500
[학술지(정기간행물)] - Bochkov VN / 2006 / Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions / Circ Res 99 : 900 ~ 908
[학술지(정기간행물)] - Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
[학술지(정기간행물)] - Augustin HG / 1994 / Differentiation of endothelial cells : analysis of the constitutive and activated endothelial cell phenotypes / Bioessays 16 : 901 ~ 906
[학술지(정기간행물)] - Li WW / 2005 / The role of therapeutic angiogenesis in tissue repair and regeneration / Adv Skin Wound Care 18 : 491 ~ 500
[학술지(정기간행물)] - Bochkov VN / 2006 / Oxidized phospholipids stimulate angiogenesis via autocrine mechanisms, implicating a novel role for lipid oxidation in the evolution of atherosclerotic lesions / Circ Res 99 : 900 ~ 908
[학술지(정기간행물)] - Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
[학술지(정기간행물)] - Augustin HG / 1994 / Differentiation of endothelial cells : analysis of the constitutive and activated endothelial cell phenotypes / Bioessays 16 : 901 ~ 906
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UCI(KEPA) : I410-ECN-0101-2018-524-001599231