지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 55 - 61 (7page)
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초록· 키워드
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Background: A number of neurological and neurodegenerative diseases share impaired cognition as a common symptom. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of Kþ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated.
Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used.
Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus.
Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.
Methods: In the current study, we took advantage of gintonin, a novel LPAR agonist, to investigate the effect of gintonin-mediated LPAR activation on cognitive performances. Hippocampus-dependent fear memory test, synaptic plasticity in the hippocampal brain slices, and quantitative analysis on synaptic plasticity-related proteins were used.
Results: Daily oral administration of gintonin for 1 wk significantly improved fear memory retention in the contextual fear-conditioning test in mice.We also found that oral administration of gintonin for 1 wk increased the expression of learning and memory-related proteins such as phosphorylated cyclic adenosine monophosphate-response element binding (CREB) protein and brain-derived neurotrophic factor (BDNF). In addition, prolonged gintonin administration enhanced long-term potentiation in the hippocampus.
Conclusion: Our observations suggest that the systemic gintonin administration could successfully improve contextual memory formation at the molecular and synaptic levels as well as the behavioral level. Therefore, oral administration of gintonin may serve as an effective noninvasive, nonsurgical method of enhancing cognitive functions.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (33)
참고문헌 신청
[학술지(정기간행물)] - Lee YS / 2009 / The molecular and cellular biology of enhanced cognition / Nat Rev Neurosci 10 : 126 ~ 140
[학술지(정기간행물)] - Choi JW / 2010 / LPA receptors: subtypes and biological actions / Annu Rev Pharmacol Toxicol 50 : 157 ~ 186
[학술지(정기간행물)] - Pilpel Y / 2006 / The role of LPA1 in formation of synapses among cultured hippocampal neurons / J Neurochem 97 : 1379 ~ 1392
[학술지(정기간행물)] - Dash PK / 2004 / A role for hippocampal Rho-ROCK pathway in long-term spatial memory / Biochem Biophys Res Commun 322 : 893 ~ 898
[학술지(정기간행물)] - Park H / 2015 / Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses / J Neurophysiol 113 : 1493 ~ 1500
[학술지(정기간행물)] - Choi JW / 2010 / LPA receptors: subtypes and biological actions / Annu Rev Pharmacol Toxicol 50 : 157 ~ 186
[학술지(정기간행물)] - Pilpel Y / 2006 / The role of LPA1 in formation of synapses among cultured hippocampal neurons / J Neurochem 97 : 1379 ~ 1392
[학술지(정기간행물)] - Dash PK / 2004 / A role for hippocampal Rho-ROCK pathway in long-term spatial memory / Biochem Biophys Res Commun 322 : 893 ~ 898
[학술지(정기간행물)] - Park H / 2015 / Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses / J Neurophysiol 113 : 1493 ~ 1500
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Gintonin absorption in intestinal model systems
Journal of Ginseng Research
2018 .01
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Gintonin influences the morphology and motility of adult brain neurons via LPA receptors
Journal of Ginseng Research
2021 .05
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Gintonin regulates inflammation in human IL-1b-stimulated fibroblast-like synoviocytes and carrageenan/kaolin-induced arthritis in rats through LPAR2
Journal of Ginseng Research
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Gintonin, an exogenous ginseng-derived LPA receptor ligand, promotes corneal wound healing
Journal of Veterinary Science
2017 .09
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Ginseng gintonin alleviates neurological symptoms in the G93A-SOD1 transgenic mouse model of amyotrophic lateral sclerosis through lysophosphatidic acid 1 receptor
Journal of Ginseng Research
2021 .05
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Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors
Journal of Ginseng Research
2021 .03
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Visualization of the binding between gintonin, a Panax ginseng-derived LPA receptor ligand, and the LPA receptor subtypes and transactivation of the EGF receptor
Journal of Ginseng Research
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Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells : involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling
Journal of Ginseng Research
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Gintonin-mediated release of astrocytic vascular endothelial growth factor protects cortical astrocytes from hypoxia-induced cell damages
Journal of Ginseng Research
2019 .04
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Gintonin facilitates catecholamine secretion from the perfused adrenal medulla
The Korean Journal of Physiology & Pharmacology
2016 .11
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Gintonin, a Panax ginseng-derived LPA receptor ligand, attenuates kainic acid-induced seizures and neuronal cell death in the hippocampus via anti-inflammatory and anti-oxidant activities
Journal of Ginseng Research
2023 .05
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Panax ginseng as an adjuvant treatment for Alzheimer’s disease
Journal of Ginseng Research
2018 .10
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Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participantblinded placebo-controlled study
Journal of Ginseng Research
2023 .11
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Corrigendum to “Gintonin regulates inflammation in human IL-1bstimulated fibroblast-like synoviocytes and carrageenan/kaolininduced arthritis in rats through LPAR2”[J Ginseng Res 45(5) September 2021, 575-582]
Journal of Ginseng Research
2023 .01
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Synaptic plasticity from memory to brain disorders
한국실험동물학회 학술발표대회 논문집
2016 .08
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Bioactive lipids in gintonin-enriched fraction from ginseng
Journal of Ginseng Research
2019 .04
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Ginseng and ginseng byproducts for skincare and skin health
Journal of Ginseng Research
2024 .11
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Visualization of synaptic plasticity regulated by Cyclin Y/CCNY
한국실험동물학회 학술발표대회 논문집
2016 .08
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Salvia miltiorrhiza Bunge Blocks Ethanol-Induced Synaptic Dysfunction through Regulation of NMDA Receptor-Dependent Synaptic Transmission
Biomolecules & Therapeutics(구 응용약물학회지)
2016 .01
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Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134emediated BDNF signaling pathway in a mouse model of chronic stress-induced depression
Journal of Ginseng Research
2022 .05
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UCI(KEPA) : I410-ECN-0101-2018-524-001598092