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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.3
- 발행연도
- 2019.9
- 수록면
- 265 - 273 (9page)
- DOI
- 10.3746/pnf.2019.24.3.265
이용수
초록· 키워드
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This study assessed the effects of probiotic supplementation on spatial learning and memory, long-term potentiation (LTP), paired-pulse facilitation (PPF) ratios, nitric oxide (NO) concentrations, and lipid profiles in a rat model of amyloid beta (Aβ)(1-42)-induced Alzheimer’s disease (AD). Forty rats were randomly divided into 4 groups. The sham (control and prevention) group received intracerebroventricular (ICV) injections of artificial cerebrospinal fluid, the Alzheimer group received ICV injection of Aβ(1-42), and the probiotic+Alzheimer group received 500 mg probiotics daily (15 ×10<SUP>9</SUP> colony-forming unit) by gavage for 4 weeks before and 2 weeks after injection of Aβ(1-42). The Morris water maze test was performed for evaluation of spatial learning and memory. LTP and PPF ratios were measured to evaluate longterm synaptic plasticity and pre-synaptic mechanisms, respectively. The results showed that probiotic supplementation significantly improved learning, but not memory impairment, and increased PPF ratios compared to those in the Alzheimer group. Both Aβ(1-42) injection and probiotic supplementation alone did not significantly effect plasma level of NO. Probiotic supplementation of rats in the probiotic (6 weeks)+Alzheimer group decreased serum levels of total cholesterol, triglyceride, and very low-density lipoprotein-cholesterol significantly compared to the Alzheimer group. The results of this study suggest that probiotic supplementation may positively impact learning capacity and LTP in rats with AD, most likely via the release of neurotransmitters via presynaptic mechanisms or via a protective effect on serum lipid profiles.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (50)
참고문헌 신청
Akbari E / 2016 / Effect of probiotic supplementation on cognitive function and metabolic status in Alzheimer’s disease: a randomized, double-blind and controlled trial / Front Aging Neurosci 8:256
Bannerman DM / 2014 / Hippocampal synaptic plasticity, spatial memory and anxiety / Nat Rev Neurosci 15:181~192
Barrett E / 2012 / Aminobutyric acid production by culturable bacteria from the human intestine / J Appl Microbiol 113:411~417
Bercik P / 2011 / The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication / Neurogastroenterol Motil 23:1132~1139
Bercik P / 2010 / Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice / Gastroenterology 139:2102~2112
Bannerman DM / 2014 / Hippocampal synaptic plasticity, spatial memory and anxiety / Nat Rev Neurosci 15:181~192
Barrett E / 2012 / Aminobutyric acid production by culturable bacteria from the human intestine / J Appl Microbiol 113:411~417
Bercik P / 2011 / The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication / Neurogastroenterol Motil 23:1132~1139
Bercik P / 2010 / Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice / Gastroenterology 139:2102~2112
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