지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 188 - 194 (7page)
이용수
초록· 키워드
오류제보하기
Background: Fermented black ginseng (FBG) is processed ginseng by the repeated heat treatment and fermentation of raw ginseng. The protective effect and mechanism of FBG on cisplatin-induced nephrotoxicity was investigated to evaluate its therapeutic potential.
Methods: The free radical scavenging activity of FBG was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH). In addition, the protective effect against cisplatin-induced renal damage was tested in rats. FBG was orally administered every day at a dose of 150 mg/kg body weight for 10 d, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) with 0.9% saline on the 4<SUP>th</SUP> d.
Results: The DPPH radical-scavenging activity of FBG (IC<SUB>50</SUB>= 384 μg/mL) was stronger than that of raw ginseng. The improved DPPH radical-scavenging activity was mediated by the generation phenolic compounds. The decreased cell viability by cisplatin was recovered significantly after treatment with FBG in a dose-dependent manner. Then, the protective effect of FBG on cisplatin-induced oxidative renal damage was investigated in rats. The decreased creatinine clearance levels, which are a reliable marker for renal dysfunction in cisplatin-treated rats, were reduced to the normal level after the administration of FBG. Moreover, FBG showed protective effects against cisplatin-induced oxidative renal damage in rats through the inhibition of NF-kB/p65, COX-2, and caspase-3 activation.
Conclusion: These results collectively show that the therapeutic evidence for FBG ameliorates the nephrotoxicity via regulating oxidative stress, inflammation, and apoptosis.
Methods: The free radical scavenging activity of FBG was measured using 1,1-diphenyl-2-picrylhydrazyl (DPPH). In addition, the protective effect against cisplatin-induced renal damage was tested in rats. FBG was orally administered every day at a dose of 150 mg/kg body weight for 10 d, and a single dose of cisplatin was administered intraperitoneally (7.5 mg/kg body weight) with 0.9% saline on the 4<SUP>th</SUP> d.
Results: The DPPH radical-scavenging activity of FBG (IC<SUB>50</SUB>= 384 μg/mL) was stronger than that of raw ginseng. The improved DPPH radical-scavenging activity was mediated by the generation phenolic compounds. The decreased cell viability by cisplatin was recovered significantly after treatment with FBG in a dose-dependent manner. Then, the protective effect of FBG on cisplatin-induced oxidative renal damage was investigated in rats. The decreased creatinine clearance levels, which are a reliable marker for renal dysfunction in cisplatin-treated rats, were reduced to the normal level after the administration of FBG. Moreover, FBG showed protective effects against cisplatin-induced oxidative renal damage in rats through the inhibition of NF-kB/p65, COX-2, and caspase-3 activation.
Conclusion: These results collectively show that the therapeutic evidence for FBG ameliorates the nephrotoxicity via regulating oxidative stress, inflammation, and apoptosis.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (44)
참고문헌 신청
[학술지(정기간행물)] - Gesler WM / 1992 / Therapeutic landscapes : medical issues in light of the new cultural geography / Soc Sci Med 34 : 735 ~ 746
[학술지(정기간행물)] - Wojcikowski K / 2004 / Medicinal herbal extractsdrenal friend or foe?: Part two. Herbal extracts with potential renal benefits / Nephrology 9 : 400 ~ 405
[학술지(정기간행물)] - Ceylan-Isik AF / 2008 / Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus / Curr Diabetes Rev 4 : 320 ~ 328
[학술지(정기간행물)] - Li X / 2009 / Organ crosstalk : the role of the kidney / Curr Opin Crit Care 15 : 481 ~ 487
[학술지(정기간행물)] - Forbes JM / 2008 / Oxidative stress as a major culprit in kidney disease in diabetes / Diabetes 57 : 1446 ~ 1454
[학술지(정기간행물)] - Wojcikowski K / 2004 / Medicinal herbal extractsdrenal friend or foe?: Part two. Herbal extracts with potential renal benefits / Nephrology 9 : 400 ~ 405
[학술지(정기간행물)] - Ceylan-Isik AF / 2008 / Herbal and traditional Chinese medicine for the treatment of cardiovascular complications in diabetes mellitus / Curr Diabetes Rev 4 : 320 ~ 328
[학술지(정기간행물)] - Li X / 2009 / Organ crosstalk : the role of the kidney / Curr Opin Crit Care 15 : 481 ~ 487
[학술지(정기간행물)] - Forbes JM / 2008 / Oxidative stress as a major culprit in kidney disease in diabetes / Diabetes 57 : 1446 ~ 1454
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UCI(KEPA) : I410-ECN-0101-2018-524-001598845