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논문 기본 정보

자료유형
학술저널
저자정보
Hyun Gyung Kim (Korea University) Sang Hoon Kim (Korea University) Taek-Seung Kim (Korea University) Tae Won Park (Chonbuk National University) Ran Won (Dongseo University) Hee-Deung Park (Korea University) Soo An Choi (Korea University) Yong Woo Jung (Korea University)
저널정보
대한면역학회 Immune Network Immune Network Vol.17 No.6
발행연도
2017.12
수록면
402 - 409 (8page)

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Carbon nanotubes (CNTs) are nanomaterials that have been employed in generating diverse materials. We previously reported that CNTs induce cell death in macrophages, possibly via asbestosis. Therefore, we generated CNT-attached polyvinylidene fluoride (PVDF), which is an established polymer in membrane technology, and then examined whether CNT-attached PVDF is immunologically safe for medical purposes compared to CNT alone. To test this, we treated RAW 264.7 murine macrophages (RAW cells) with CNT-attached PVDF and analyzed the production of nitric oxide (NO), a potent proinflammatory mediator, in these cells. RAW cells treated with CNT-attached PVDF showed reduced NO production in response to lipopolysaccharide. However, the same treatment also decreased the cell number suggesting that this treatment can alter the homeostasis of RAW cells. Although cell cycle of RAW cells was increased by PVDF treatment with or without CNTs, apoptosis was enhanced in these cells. Taken together, these results indicate that PVDF with or without CNTs modulates inflammatory responses possibly due to activation-induced cell death in macrophages.

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ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
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UCI(KEPA) : I410-ECN-0101-2018-517-001663351