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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 229 - 250 (22page)
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The notion that obesity-induced inflammation mediates the development of insulin resistance in animal models and humans has been gaining strong support. It has also been shown that immune cells in local tissues, in particular in visceral adipose tissue, play a major role in the regulation of obesity-induced inflammation. Specifically, obesity increases the numbers and activation of proinflammatory immune cells, including M1 macrophages, neutrophils, Th1 CD4 T cells, and CD8 T cells, while simultaneously suppressing anti-inflammatory cells such as M2 macrophages, CD4 regulatory T cells, regulatory B cells, and eosinophils. Recently, however, new cell types have been shown to participate in the development of obesity-induced inflammation and insulin resistance. Some of these cell types also appear to regulate obesity. These cells are natural killer (NK) cells and innate lymphoid cells (ILCs), which are closely related, and invariant natural killer T (iNKT) cells. It should be noted that, although iNKT cells resemble NK cells in name, they are actually a completely different cell type in terms of their development and functions in immunity and metabolism. In this review, we will focus on the roles that these relatively new players in the metabolism field play in obesity-induced insulin resistance and the regulation of obesity.
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참고문헌 (91)
참고문헌 신청
Ogden CL / 2014 / Prevalence of childhood and adult obesity in the United States, 2011-2012 / JAMA 311:806~814
NCD Risk Factor Collaboration (NCD-RisC) / 2016 / Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants / Lancet 387:1377~1396
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Lee BC / 2014 / Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance / Biochim Biophys Acta 1842:446~462
Zak DE / 2014 / Systems-level analysis of innate immunity / Annu Rev Immunol 32:547~577
NCD Risk Factor Collaboration (NCD-RisC) / 2016 / Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants / Lancet 387:1377~1396
Shoelson SE / 2006 / Inflammation and insulin resistance / J Clin Invest 116:1793~1801
Lee BC / 2014 / Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance / Biochim Biophys Acta 1842:446~462
Zak DE / 2014 / Systems-level analysis of innate immunity / Annu Rev Immunol 32:547~577
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