지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 131 - 137 (7page)
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Purpose: Programmed death-1 and its ligands (PD-L1 and PD-L2) can induce T-cell apoptosis in many solid tumors, although there is limited information regarding their roles in colorectal cancer.
Methods: We used immunohistochemistry to retrospectively examine expressions of PD-L1 and PD-L2 in paraffin-embedded specimens from 104 patients with colorectal cancer.
Results: Among the 104 included patients, 31 patients (29.8%) had positive PD-L1 expression and 73 patients (70.2%) had negative PD-L1 expression. Positive PD-L2 expression was observed in 83 patients (79.8%) and negative PD-L2 expression was observed in 21 patients (20.2%). Positive PD-L1 expression group showed higher overall survival rate (OS) and disease-free survival (DFS) than negative PD-L1 expression group. However, the overall survival and DFS were not significantly different between positive and negative PD-L2 expressions group. The multivariate analyses revealed that short OS was independently associated with positive PD-L1 expression (hazard ratio [HR], 2.781; 95% confidence interval [CI], 1.284–6.026; P=0.01), regional lymph node status (HR, 2.611; 95% CI, 1.258–5.418; P=0.01), and distant metastasis (HR, 4.279; 95% CI, 1.449–12.638; P=0.009). In addition, short DFS was independently associated with positive PD-L1 expression (HR, 2.846; 95% CI, 1.393–5.815; P=0.004) and regional lymph node status (HR, 2.310; 95% CI, 1.122–4.758; P=0.023).
Conclusion: Although prospective multi-center studies are needed to validate our findings, we found that PD-L1 expression predicted OS and DFS among patients with colorectal cancer.
Methods: We used immunohistochemistry to retrospectively examine expressions of PD-L1 and PD-L2 in paraffin-embedded specimens from 104 patients with colorectal cancer.
Results: Among the 104 included patients, 31 patients (29.8%) had positive PD-L1 expression and 73 patients (70.2%) had negative PD-L1 expression. Positive PD-L2 expression was observed in 83 patients (79.8%) and negative PD-L2 expression was observed in 21 patients (20.2%). Positive PD-L1 expression group showed higher overall survival rate (OS) and disease-free survival (DFS) than negative PD-L1 expression group. However, the overall survival and DFS were not significantly different between positive and negative PD-L2 expressions group. The multivariate analyses revealed that short OS was independently associated with positive PD-L1 expression (hazard ratio [HR], 2.781; 95% confidence interval [CI], 1.284–6.026; P=0.01), regional lymph node status (HR, 2.611; 95% CI, 1.258–5.418; P=0.01), and distant metastasis (HR, 4.279; 95% CI, 1.449–12.638; P=0.009). In addition, short DFS was independently associated with positive PD-L1 expression (HR, 2.846; 95% CI, 1.393–5.815; P=0.004) and regional lymph node status (HR, 2.310; 95% CI, 1.122–4.758; P=0.023).
Conclusion: Although prospective multi-center studies are needed to validate our findings, we found that PD-L1 expression predicted OS and DFS among patients with colorectal cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (25)
참고문헌 신청
[학술지(정기간행물)] - Siegel RL / 2017 / Colorectal cancer statistics, 2017 / CA Cancer J Clin 67 : 177 ~ 193
[인터넷자원] - Statistics Korea / / Cancer incidence and mortality in Korea, 2016
[학술지(정기간행물)] - Sharma P / 2015 / Immune checkpoint targeting in cancer therapy:toward combination strategies with curative potential / Cell 161 : 205 ~ 214
[학술지(정기간행물)] - Galon J / 2006 / Type, density, and location of immune cells within human colorectal tumors predict clinical outcome / Science 313 : 1960 ~ 1964
[학술지(정기간행물)] - Pages F / 2005 / Effector memory T cells, early metastasis, and survival in colorectal cancer / N Engl J Med 353 : 2654 ~ 2666
[인터넷자원] - Statistics Korea / / Cancer incidence and mortality in Korea, 2016
[학술지(정기간행물)] - Sharma P / 2015 / Immune checkpoint targeting in cancer therapy:toward combination strategies with curative potential / Cell 161 : 205 ~ 214
[학술지(정기간행물)] - Galon J / 2006 / Type, density, and location of immune cells within human colorectal tumors predict clinical outcome / Science 313 : 1960 ~ 1964
[학술지(정기간행물)] - Pages F / 2005 / Effector memory T cells, early metastasis, and survival in colorectal cancer / N Engl J Med 353 : 2654 ~ 2666
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UCI(KEPA) : I410-ECN-0101-2018-514-001685098