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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제6호
- 발행연도
- 2021.11
- 수록면
- 388 - 397 (10page)
- DOI
- 10.4132/jptm.2021.08.04
이용수
초록· 키워드
오류제보하기
Background: Glioblastoma is the most aggressive primary malignant brain tumor in adults and is characterized by poor prognosis. Immune evasion occurs via programmed death-ligand 1 (PD-L1)/programmed death receptor 1 (PD-1) interaction. Some malignant tumors have responded to PD-L1/PD-1 blockade treatment strategies, and PD-L1 has been described as a potential predictive biomarker. This study discussed the expression of PD-L1 and CD8 in glioblastomas.Methods: Thirty cases of glioblastoma were stained immunohistochemically for PD-L1 and CD8, where PD-L1 expression in glioblastoma tumor tissue above 1% is considered positive and CD-8 is expressed in tumor infiltrating lymphocytes. The expression of each marker was correlated with clinicopathologic parameters. Survival analysis was conducted to correlate progression-free survival (PFS) and overall survival (OS) with PD-L1 and CD8 expression.Results: Diffuse/fibrillary PD-L1 was expressed in all cases (mean expression, 57.6%), whereas membranous PD-L1 was expressed in six of 30 cases. CD8-positive tumor-infiltrating lymphocytes (CD8+ TILs) had a median expression of 10%. PD-L1 and CD8 were positively correlated (p = .001). High PD-L1 expression was associated with worse PFS and OS (p = .026 and p = .001, respectively). Correlation of CD8+ TILs percentage with age, sex, tumor site, laterality, and outcomes were statistically insignificant. Multivariate analysis revealed that PD-L1 was the only independent factor that affected prognosis.Conclusions: PD-L1 expression in patients with glioblastoma is robust; higher PD-L1 expression is associated with lower CD8+ TIL expression and worse prognosis.
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참고문헌 (39)
참고문헌 신청
Szopa W / 2017 / Diagnostic and therapeutic biomarkers in glioblastoma : current status and future perspectives / Biomed Res Int 2017:8013575
Xue S / 2017 / Relationship between expression of PD-L1and tumor angiogenesis, proliferation, and invasion in glioma / Oncotarget 8:49702~49712
Nduom EK / 2016 / PD-L1 expression and prognostic impact in glioblastoma / Neuro Oncol 18:195~205
Liu Y / 2013 / PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients / J Neurosci 33:14231~14245
Louis DN / 2016 / WHO classification of tumours of the central nervous system / IARC Press
Xue S / 2017 / Relationship between expression of PD-L1and tumor angiogenesis, proliferation, and invasion in glioma / Oncotarget 8:49702~49712
Nduom EK / 2016 / PD-L1 expression and prognostic impact in glioblastoma / Neuro Oncol 18:195~205
Liu Y / 2013 / PD-L1 expression by neurons nearby tumors indicates better prognosis in glioblastoma patients / J Neurosci 33:14231~14245
Louis DN / 2016 / WHO classification of tumours of the central nervous system / IARC Press
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