지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.94 No.1
- 발행연도
- 2018.1
- 수록면
- 13 - 18 (6page)
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초록· 키워드
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Purpose: The detection rate of brain metastasis (BM) from colorectal cancer (CRC) is increasing. This study was designed to analyze the clinical features of BM and prognosis according to the therapeutic modalities.
Methods: A total of 19 cases were collected in this study between November 2008 and December 2015. We reviewed the patients’ demographic data and the clinical features of BM retrospectively and investigated their prognostic significance.
Results: Nineteen patients included 8 male and 11 female patients. The median age at diagnosis of BM was 62.4 years (range, 32.83 years). The median interval between diagnosis of CRC and BM was 39 months (range, 0.98 months). Eighteen patients (94.7%) had extracranial metastasis at the diagnosis of BM. Lung was the most common site of extracranial metastasis in 14 patients (73.7%). Synchronous BMs were found at the diagnosis of primary CRC in 2 patients (10.5%). The location of primary CRC was the colon in 6 patients (31.6%) and the rectum in 13 patients (68.4%). At the diagnosis of BM, 10 patients (52.6%) had a solitary BM. The common neurologic symptoms were headache in 8 cases (42.1%) and ataxia in 6 cases (31.6%). The median survival after the diagnosis of BM was 3 months (range, 1.10 months). The patients who underwent surgery plus stereotactic radiosurgery (SRS) had an improved survival (range, 3.10 months) than the other patients (range, 1-6 months) (P = 0.016).
Conclusion: In patients with BM from CRC, surgical resection plus SRS might improve survival.
Methods: A total of 19 cases were collected in this study between November 2008 and December 2015. We reviewed the patients’ demographic data and the clinical features of BM retrospectively and investigated their prognostic significance.
Results: Nineteen patients included 8 male and 11 female patients. The median age at diagnosis of BM was 62.4 years (range, 32.83 years). The median interval between diagnosis of CRC and BM was 39 months (range, 0.98 months). Eighteen patients (94.7%) had extracranial metastasis at the diagnosis of BM. Lung was the most common site of extracranial metastasis in 14 patients (73.7%). Synchronous BMs were found at the diagnosis of primary CRC in 2 patients (10.5%). The location of primary CRC was the colon in 6 patients (31.6%) and the rectum in 13 patients (68.4%). At the diagnosis of BM, 10 patients (52.6%) had a solitary BM. The common neurologic symptoms were headache in 8 cases (42.1%) and ataxia in 6 cases (31.6%). The median survival after the diagnosis of BM was 3 months (range, 1.10 months). The patients who underwent surgery plus stereotactic radiosurgery (SRS) had an improved survival (range, 3.10 months) than the other patients (range, 1-6 months) (P = 0.016).
Conclusion: In patients with BM from CRC, surgical resection plus SRS might improve survival.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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UCI(KEPA) : I410-ECN-0101-2018-514-001683796