지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.94 No.4
- 발행연도
- 2018.4
- 수록면
- 183 - 189 (7page)
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초록· 키워드
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Purpose: Preoperative F-18-fluoro-2-deoxy-glucose positron emission tomography (18F-FDG PET) imaging results appear to predict tumor recurrence and patient survival. The present study compared outcomes between PET-positive and PETnegative groups with HBV-related hepatocellular carcinoma (HCC) who underwent curative hepatectomy and assessed the prognostic value of positive PET-CT for HCC recurrence and death.
Methods: This study included patients who underwent liver resection of solitary HCC between 2007 and 2014 based on preoperative radiological images. There were 133 patients in the PET-positive group and 93 in the PET-negative group.
Results: There were no statistically significant differences in baseline, perioperative, or pathologic characteristics between the 2 groups except HBsAg titer, tumor size, and presence of bile duct tumor thrombi. Multivariate analysis showed that tumor size >3.5 cm and HBsAg titer >1,000 cutoff index were predisposing factors of positive PET-CT. Disease-free survival and overall survival rate at 1, 3, and 5 years were 76.3%, 64.4%, 60.3% and 96.8%, 91.1%, 85.1% in the PET-negative group, respectively, compared with 70.7%, 62.2%, 58.9% and 98.5%, 97.0%, 97.0% in the PET-positive group (P = 0.547 and P = 0.046). Multivariate analysis showed that positive PET-CT was closely associated with increased patient survival, but was not related to HCC recurrence.
Conclusion: These results suggest that positive PET findings are not a predisposing factor for recurrence of HBV-related HCC patients, but appear to be associated with improved patient survival. Further prospective studies are needed to confirm the prognostic value of 18F-FDG PET in these patients.
Methods: This study included patients who underwent liver resection of solitary HCC between 2007 and 2014 based on preoperative radiological images. There were 133 patients in the PET-positive group and 93 in the PET-negative group.
Results: There were no statistically significant differences in baseline, perioperative, or pathologic characteristics between the 2 groups except HBsAg titer, tumor size, and presence of bile duct tumor thrombi. Multivariate analysis showed that tumor size >3.5 cm and HBsAg titer >1,000 cutoff index were predisposing factors of positive PET-CT. Disease-free survival and overall survival rate at 1, 3, and 5 years were 76.3%, 64.4%, 60.3% and 96.8%, 91.1%, 85.1% in the PET-negative group, respectively, compared with 70.7%, 62.2%, 58.9% and 98.5%, 97.0%, 97.0% in the PET-positive group (P = 0.547 and P = 0.046). Multivariate analysis showed that positive PET-CT was closely associated with increased patient survival, but was not related to HCC recurrence.
Conclusion: These results suggest that positive PET findings are not a predisposing factor for recurrence of HBV-related HCC patients, but appear to be associated with improved patient survival. Further prospective studies are needed to confirm the prognostic value of 18F-FDG PET in these patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
[학술지(정기간행물)] - Kim JM / 2013 / The effect of alkaline phosphatase and intrahepatic metastases in large hepatocellular carcinoma / World J Surg Oncol 11 : 40 ~
[학술지(정기간행물)] - Kim JM / 2013 / C-reactive protein may be a prognostic factor in hepatocellular carcinoma with malignant portal vein invasion / World J Surg Oncol 11 : 92 ~
[학술지(정기간행물)] - Kim JM / 2013 / Protein induced by vitamin K antagonist-II (PIVKA-II) is a reliable prognostic factor in small hepatocellular carcinoma / World J Surg 37 : 1371 ~ 1378
[학술지(정기간행물)] - Kim JM / 2014 / Differences between hepatocellular carcinoma and hepatitis B virus infection in patients with and without cirrhosis / Ann Surg Oncol 21 : 458 ~ 465
[학술지(정기간행물)] - Asman Y / 2015 / [18F]fludeoxyglucose positron emission tomography and computed tomography as a prognostic tool before liver transplantation, resection, and locoablative therapies for hepatocellular carcinoma / Liver Transpl 21 : 572 ~ 580
[학술지(정기간행물)] - Kim JM / 2013 / C-reactive protein may be a prognostic factor in hepatocellular carcinoma with malignant portal vein invasion / World J Surg Oncol 11 : 92 ~
[학술지(정기간행물)] - Kim JM / 2013 / Protein induced by vitamin K antagonist-II (PIVKA-II) is a reliable prognostic factor in small hepatocellular carcinoma / World J Surg 37 : 1371 ~ 1378
[학술지(정기간행물)] - Kim JM / 2014 / Differences between hepatocellular carcinoma and hepatitis B virus infection in patients with and without cirrhosis / Ann Surg Oncol 21 : 458 ~ 465
[학술지(정기간행물)] - Asman Y / 2015 / [18F]fludeoxyglucose positron emission tomography and computed tomography as a prognostic tool before liver transplantation, resection, and locoablative therapies for hepatocellular carcinoma / Liver Transpl 21 : 572 ~ 580
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UCI(KEPA) : I410-ECN-0101-2018-514-001913146