지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.102 No.3
- 발행연도
- 2022.3
- 수록면
- 131 - 138 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: Early recurrence of hepatocellular carcinoma (HCC) remains a challenging issue after hepatic resection (HR) because of the associated poor prognosis. Models for tumor recurrence after liver transplantation (MoRAL) have been designed to predict tumor recurrence in HCC patients in the liver transplantation setting. This study aimed to validate the predictability of MoRAL for HCC recurrence or patient death and to evaluate the predictors of early HCC recurrence in hepatectomy patients with treatment-naïve solitary HCC.
Methods: This study included 443 patients with HCC recurrence after HR from January 2005 to December 2011. Patients were stratified into early recurrence (n = 312) and late recurrence (n = 131) groups according to the development of recurrence either within or more than 2 years after hepatectomy.
Results: The median levels of alpha-fetoprotein and protein induced by vitamin K absence-II and the median MoRAL score were significantly higher in the early recurrence group than in the late recurrence group. Regarding pathologic characteristics, the median tumor size, prevalence of tumor grade 3 or 4, microvascular invasion, presence of tumor necrosis, and macrovascular invasion in the early recurrence group were greater than those in the late recurrence group. Multivariate analysis showed that tumor grade 3 or 4, microvascular invasion, and high preoperative MoRAL score were predisposing factors for early HCC recurrence after HR.
Conclusion: The MoRAL score can be used to predict early recurrence in patients with HCC who undergo curative HR. Using this model, other treatments could be considered for patients with early recurrence predicted after HR.
Methods: This study included 443 patients with HCC recurrence after HR from January 2005 to December 2011. Patients were stratified into early recurrence (n = 312) and late recurrence (n = 131) groups according to the development of recurrence either within or more than 2 years after hepatectomy.
Results: The median levels of alpha-fetoprotein and protein induced by vitamin K absence-II and the median MoRAL score were significantly higher in the early recurrence group than in the late recurrence group. Regarding pathologic characteristics, the median tumor size, prevalence of tumor grade 3 or 4, microvascular invasion, presence of tumor necrosis, and macrovascular invasion in the early recurrence group were greater than those in the late recurrence group. Multivariate analysis showed that tumor grade 3 or 4, microvascular invasion, and high preoperative MoRAL score were predisposing factors for early HCC recurrence after HR.
Conclusion: The MoRAL score can be used to predict early recurrence in patients with HCC who undergo curative HR. Using this model, other treatments could be considered for patients with early recurrence predicted after HR.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Substantial risk of recurrence even after 5 recurrence-free years in early-stage hepatocellular carcinoma patients
Clinical and Molecular Hepatology
2020 .01
-
Protrusion of hepatocellular carcinoma is a predictor of early recurrence in hepatectomy patients after spontaneous rupture
Annals of Surgical Treatment and Research
2016 .06
-
Change in the Recurrence Pattern and Predictors over Time after Complete Cure of Hepatocellular Carcinoma
Gut and Liver
2021 .01
-
Early disseminated recurrence after liver resection in solitary hepatocellular carcinoma
Annals of Surgical Treatment and Research
2018 .03
-
A comparison of the risk factors of intrahepatic recurrence, early recurrencen, and multiple recurrences after resection for single nodular hepatocellular carcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2015 .08
-
Differences in Prognostic Factors between Early and Late Recurrence Breast Cancers
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Risk factors for poor survival after recurrence of hepatocellular carcinoma after liver transplantation
Annals of Surgical Treatment and Research
2021 .07
-
Outcomes of Living Donor Liver Transplantation in Patients with a History of Ruptured Hepatocellular Carcinoma
대한외과학회 학술대회 초록집
2021 .05
-
Prediction models of hepatocellular carcinoma recurrence after liver transplantation: A comprehensive review
Clinical and Molecular Hepatology
2022 .10
-
Independent Risk Factors for Hepatocellular Carcinoma Recurrence after Direct-Acting Antiviral Therapy in Patients with Chronic Hepatitis C
Gut and Liver
2021 .01
-
Tumor Location Causes Different Recurrence Patterns in Remnant Gastric Cancer
Journal of Gastric Cancer
2022 .10
-
Prognosis of Hepatocellular Carcinoma after Liver Transplantation: Comparative Analysis with Partial Hepatectomy
Journal of Pathology and Translational Medicine
2017 .01
-
Clinical significance and predictive factors of early massive recurrence after radiofrequency ablation in patients with a single small hepatocellular carcinoma
Clinical and Molecular Hepatology
2016 .01
-
Blood Neutrophil-to-Lymphocyte Ratio Predicts Tumor Recurrence in Patients with Hepatocellular Carcinoma within Milan Criteria after Hepatectomy
Yonsei Medical Journal
2016 .01
-
Prognosis after intrahepatic recurrence in the patients who underwent curative resection for hepatocellular carcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .11
-
Prognosis according to the timing of recurrence in breast cancer
Annals of Surgical Treatment and Research
2023 .01
-
Which Patients Should We Follow up beyond 5 Years after Definitive Therapy for Localized Renal Cell Carcinoma?
Cancer Research and Treatment
2015 .01
-
Identifying Predictive Factors for the Recurrence of Pediatric Intussusception
Pediatric Gastroenterology, Hepatology & Nutrition
2019 .01
-
Appropriate treatment modality for solitary small hepatocellular carcinoma: Radiofrequency ablation vs. resection vs. transplantation?
Clinical and Molecular Hepatology
2019 .01
-
Is the anatomical resection necessary for single hepatocellular carcinoma smaller than 3 cm? : single-center experience of liver resection for a small HCC
Annals of Hepato-Biliary-Pancreatic Surgery
2018 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-514-000221324