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Portulaca oleracea L. Extract Lowers Postprandial Hyperglycemia by Inhibiting Carbohydrate-digesting Enzymes
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Type
Academic journal
Author
Jae-Eun Park (Pusan National University) Ji-Sook Han (Pusan National University)
Journal
Korean Society Of Life Science Journal of Life Science Vol.28 No.4 KCI Accredited Journals
Published
2018.4
Pages
421 - 428 (8page)

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Portulaca oleracea L. Extract Lowers Postprandial Hyperglycemia by Inhibiting Carbohydrate-digesting Enzymes
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Postprandial hyperglycemia plays an important role in the development of Type 2 Diabetes and diabetic complications. Controlling postprandial hyperglycemia is the most important factor for reducing the risks of diabetic complications in Type 2 diabetic patients. This study was designed to determine whether Portulaca oleracea L. extract suppresses the activation of carbohydrate-digesting enzymes, and lowers postprandial hyperglycemia in diabetic mice through streptozotocin. P. oleracea was extracted with either 80% ethanol (PEE) or water (PWE), and the extract solutions were concentrated. The α-glucosidase and α-amylase inhibition assays were performed using the chromogenic method. Normal mice and STZ-induced diabetic mice were orally treated with PEE, PWE (300 mg/kg of body weight) or acarbose (100 mg/kg of body weight), with soluble starch (2 g/kg of body weight). The α-glucosidase and α-amylase inhibitory effectiveness by PEE were markedly more effective than PWE, and both extracts indicated a higher effectiveness than the acarbose (positive control). The rise in postprandial blood glucose due to starch loading was markedly inhibited in the PEE group when compared to the control group in diabetic and normal mice. Furthermore, the area under the concentration–time curve values were markedly declined by the PEE injection in the diabetic group when compared to that exerted for the control group. These results demonstrate that P. oleracea extracts lower postprandial hyperglycemia by inhibiting carbohydrate-digesting enzymes, and that the ethanol extract is more efficacious than the water extract.
#α-amylase #α-glucosidase #diabetes #Portulaca oleracea L. #postprandial hyperglycemia

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Introduction
Materials and Methods
Results and Discussion
References
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References (37)

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Barakat, L. A. and Mahmoud, R. H. 2011. The antiatherogenic, renal protective and immunomodulatory effects of purslane, pumpkin and flax seeds on hypercholesterolemic rats. N. Am. J. Med. Sci. 3, 351-357. Baron, A. D. 1998. Postprandial hyperglycemia and α-glucosidase inhibitors. Diabetes Res. Clin. Pract. 40, 51-55. Bhandari, M. R., Anurakkun, N. J., Hong, G. and Kawabata, J. 2008. α-Glucosidase and α-amylase inhibitory activities of Nepalese medicinal herb Pakhanbhed (Bergenia ciliata, Haw.). Food Chem. 106, 247-252. Ceriello, A. 2005. Postprandial hyperglycemia and diabetes complications: is it time to treat? Diabetes 54, 1-7. Chai, T. T., Kwek, M. T., Ong, H. C. and Wong, F. C. 2015. Water fraction of edible medicinal fern Stenochlaena palustris is a potent α-glucosidase inhibitor with concurrent antioxidant activity. Food Chem. 186, 26-31.

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UCI(KEPA) : I410-ECN-0101-2018-470-002101838