지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.4
- 수록면
- 68 - 79 (12page)
이용수
초록· 키워드
오류제보하기
Bone marrow-derived dendritic cells (BM-DCs) are generated from bone marrow (BM) cells cultured with granulocyte macrophage-colony stimulating factor (GM-CSF) for a week. In this study we investigated the effect of duration on the BM culture with GM-CSF. Within several months, the cells in the BM culture gradually expressed homogeneous levels of CD11c and major histocompatibility complex II on surface, and they became unable to stimulate allogeneic naïve T cells in mixed lymphocyte reaction (MLR). In addition, when the BM culture were sustained for 32 wk or longer, the BM cells acquired ability to suppress the proliferation of allogeneic T cells in MLR as well as the response of ovalbumin-specific OT-I transgenic T cells in antigen-dependent manner. We found that, except for programmed death-ligand 1, most cell surface molecules were expressed lower in the BM cells cultured with GM-CSF for the extended duration. These results indicate that BM cells in the extended culture with GM-CSF undergo 2 distinct steps of functional change; first, they lose the immunostimulatory capacity; and next, they gain the immunosuppressive ability.
목차
ABSTRACT
INTROCUDTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Steinman RM / 1978 / Lymphoid dendritic cells are potent stimulators of the primary mixed leukocyte reaction in mice / Proc Natl Acad Sci U S A 75:5132~5136
Steinman RM / 2012 / Decisions about dendritic cells: past, present, and future / Annu Rev Immunol 30:1~22
Park CG / 2014 / Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo / Clin Exp Vaccine Res 3:149~154
Fogg DK / 2006 / A clonogenic bone marrow progenitor specific for macrophages and dendritic cells / Science 311:83~87
Liu K / 2009 / In vivo analysis of dendritic cell development and homeostasis / Science 324:392~397
Steinman RM / 2012 / Decisions about dendritic cells: past, present, and future / Annu Rev Immunol 30:1~22
Park CG / 2014 / Vaccine strategies utilizing C-type lectin receptors on dendritic cells in vivo / Clin Exp Vaccine Res 3:149~154
Fogg DK / 2006 / A clonogenic bone marrow progenitor specific for macrophages and dendritic cells / Science 311:83~87
Liu K / 2009 / In vivo analysis of dendritic cell development and homeostasis / Science 324:392~397
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genomic and Transcriptomic Characterization of Gastric Cancer with Bone Metastasis
Cancer Research and Treatment
2024 .01
-
구강작열감 증후군
대한치과의사협회지
2017 .09
-
Anti-inflammatory activity of Caesalpinia sappan extract on lipopolysaccharide-treated bone marrow cells
예방수의학회지
2018 .09
-
Evaluation of the effects of disulfiram, an alcohol-aversive agent with anti-cancer activity, on mouse bone marrow cells
The Korean Journal of Physiology & Pharmacology
2022 .05
-
Treatment for Burning Mouth Syndrome: A Clinical Review
Journal of Oral Medicine and Pain
2023 .03
-
Anti-inflammatory activity of Rhus chinensis extract on bone marrow cells via decrease of metabolic activity and modulation of the production of inflammation-related cytokines
예방수의학회지
2017 .03
-
Combined Effect of Granulocyte-Colony-Stimulating Factor-Induced Bone Marrow-Derived Stem Cells and Red Ginseng in Patients with Decompensated Liver Cirrhosis (Combined Effect of G-CSF and Red Ginseng in Liver Cirrhosis)
대한한의학회지
2016 .12
-
Inhibition of hepatic stellate cells by bone marrow-derived mesenchymal stem cells in hepatic fibrosis
Clinical and Molecular Hepatology
2015 .01
-
Comparative characteristic study from bone marrow-derived mesenchymal stem cells
Journal of Veterinary Science
2021 .11
-
Determination of the toxicity of enrofloxacin on mouse bone marrow cells
예방수의학회지
2019 .01
-
Regulation of Th2 Cell Immunity by Dendritic Cells
Immune Network
2016 .02
-
Psychological Aspects of Burning Mouth Syndrome
Journal of Oral Medicine and Pain
2015 .03
-
Induction of CD4⁺ Regulatory and Polarized Effector/helper T Cells by Dendritic Cells
Immune Network
2016 .02
-
Masticatory muscle tenderness in burning mouth syndrome: A case control study
Oral Biology Research
2019 .01
-
Attenuation of Hepatic Graft-versus-host Disease in Allogeneic Recipients of MyD88-deficient Donor Bone Marrow
Immune Network
2015 .06
-
Application of Biomarkers for the Prediction and Diagnosis of Bone Metastasis in Breast Cancer
Journal of Breast Cancer
2020 .01
-
Innate Immunological Function of Bystander CD4 T Cells in Autoimmunity
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Correlation Between Bone Marrow Blasts Counts With Flow Cytometry and Morphological Analysis in Myelodysplastic Syndromes
Annals of Laboratory Medicine
2017 .01
-
The effects of BMS-470539 on lipopolysaccharideinduced acute lung injury
Acute and Critical Care
2019 .01
-
Clonal Expansion of Allergen-specific CD4+ T Cell in the Lung in the Absence of Lymph Nodes
Immune Network
2017 .06
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-517-002013108