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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.23 No.3
- 발행연도
- 2018.9
- 수록면
- 206 - 213 (8page)
- DOI
- 10.3746/pnf.2018.23.3.206
이용수
초록· 키워드
오류제보하기
Mondia whitei is an African traditional spice with aphrodisiac properties. Inhibition of mitochondrial permeability transition (mPT) pore is an important cytoprotective process essential for cell survival. In this study, the effects of methanol extract (ME), dichloromethane (DCMF), ethyl acetate (EF), and methanol fractions (MF) of Mondia whitei on mPT, mitochondrial ATPase, lipid peroxidation, testosterone hormone (TH), luteinizing hormone (LH), and follicle stimulating hormone (FSH) were investigated; sperm analyses were also carried out. Male experimental rats were treated intraperitoneally with 25, 50, and 100 mg/kg bw of ME, DCMF, EF, and MF of Mondia whitei for two weeks. The positive and the negative controls received sildenafil citrate and the vehicle, respectively. The results showed that mPT was inhibited by MF at the highest dose. The ME, DCMF, and MF did not enhance ATPase activity. The levels of TH, FSH, and LH varied linearly with the drug dose only in EF. Malondialdehyde levels in the treated groups were significantly higher than the normal control. There were no significant defects in sperm produced by the animals in all the treated groups relative to the control. This study showed that the extract and fractions of Mondia whitei have cytoprotective effects and may prevent mitochondrial-mediated cell death.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Oketch-Rabah HA / 2012 / Mondia whitei, a medicinal plant from Africa with aphrodisiac and antidepressant properties: a review / J Diet Suppl 9 : 272 ~ 284
[학술지(정기간행물)] - Watcho P / 2004 / Androgenic effect of Mondia whitei roots in male rats / Asian J Androl 6 : 269 ~ 272
[학술지(정기간행물)] - Watcho P / 2005 / Effects of the hexane extract of Mondia whitei on the reproductive organs of male rat / Afr J Tradit Complementary Altern Med 2 : 302 ~ 311
[학술지(정기간행물)] - Kuete V / 2011 / Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts / J Ethnopharmacol 134 : 803 ~ 812
[학술지(정기간행물)] - Miller WL / 2013 / Steroid hormone synthesis in mitochondria / Mol Cell Endocrinol 379 : 62 ~ 73
[학술지(정기간행물)] - Watcho P / 2004 / Androgenic effect of Mondia whitei roots in male rats / Asian J Androl 6 : 269 ~ 272
[학술지(정기간행물)] - Watcho P / 2005 / Effects of the hexane extract of Mondia whitei on the reproductive organs of male rat / Afr J Tradit Complementary Altern Med 2 : 302 ~ 311
[학술지(정기간행물)] - Kuete V / 2011 / Cytotoxicity of some Cameroonian spices and selected medicinal plant extracts / J Ethnopharmacol 134 : 803 ~ 812
[학술지(정기간행물)] - Miller WL / 2013 / Steroid hormone synthesis in mitochondria / Mol Cell Endocrinol 379 : 62 ~ 73
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