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Comparison of the Cholesterol-lowering Effects between Loquat Leaf and Fruit Extract in Rats Fed a High-cholesterol Diet
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비파 잎 및 열매 추출물이 고콜레스테롤 식이를 급여한 흰쥐의 콜레스테롤 저하효과 비교

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Type
Academic journal
Author
Sea Jung Kim (조선대학교) Sihoon Park (조선대학교) Jae-Joon Lee (조선대학교)
Journal
The Korean Society of Community Living Science The Korean Journal of Community Living Science Vol.29 No.4 KCI Accredited Journals
Published
2018.11
Pages
495 - 505 (11page)
DOI
10.7856/kjcls.2018.29.4.495

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Comparison of the Cholesterol-lowering Effects between Loquat Leaf and Fruit Extract in Rats Fed a High-cholesterol Diet
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This study compared the cholesterol lowering effects of loquat leaf and the fruit ethanol extracts on rats fed a high-cholesterol diet. Male Sprague-Dawley rats were divided into 4 groups: normal diet group (ND), high-cholesterol diet group (HCD), high-cholesterol diet and loquat leaf with 400 mg/kg treated group (HCD-LLE), and high-cholesterol diet and loquat fruit with 400 mg/kg treated group (HCD-LFE). No significant differences were found in body weight gain, food intake, adipose tissue weight, serum LDH activities, triglyceride (TG), and hepatic and fecal total lipid contents in both the normal (ND) and high-cholesterol diet fed groups (HCD, HCD-LLE, HCD-LFE). The serum ALT, AST and ALP activities, total cholesterol (TC), LDL-cholesterol, atherogenic index, cardiac risk factor, and hepatic TC contents were significantly lower in the HCD-LLE and HCD-LFE groups, whereas the HCD-LLE group showed a significantly higher serum HLD-cholesterol, and fecal TC and total bile acid content than the HCD and HCD-LLE groups. The cholesterol-lowering effects were greater in the HCD-LLE group than in the HCD-LFE group. These results suggest that loquat ethanol extracts may improve the serum and hepatic lipid profiles, and enhance the fecal excretion of lipids in mice fed a high-cholesterol diet.
#loquat extract #high-cholesterol diet #lipid profiles #rat

Contents

ABSTRACT
I. 서론
Ⅱ. 연구방법
Ⅲ. 결과 및 고찰
Ⅳ. 요약 및 결론
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